Collagen and Hyaluronic Acid Intra-Articular Injections Market Report Scope & Overview:

The collagen and hyaluronic acid intra-articular injections market was valued at USD 3.03 billion in 2024 and is expected to reach USD 4.86 billion by 2032, growing at a CAGR of 6.10% over the forecast period of 2025-2032. 

The global collagen and hyaluronic acid intra-articular injections market is being driven by the rising need for non-surgical, minimally invasive treatments. Patients said they would prefer injections to joint replacement surgeries due to faster recovery times, lower complication rate, and also the injections would be less costly. Furthermore, the major collagen and hyaluronic acid intra-articular injections market trend is the increasing focus on evolving formulations such as one-injection HA solutions and combined treatment for sustained relief and superior joint lubrication.

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For instance, in June 2025, Fidia Farmaceutici initiated clinical development of an HA + collagen combination injection targeting joint regeneration, supporting trends in advanced, multifunctional intra-articular formulations for joint recovery.

For instance, in April 2025, Anika Therapeutics expanded the U.S. trials for a next-gen hyaluronic acid–collagen injectable, boosting innovation and reinforcing the U.S. dominance in the intra-articular injections market.

Key Collagen and Hyaluronic Acid Intra-Articular Injections Market Trends

• Next-gen viscosupplement delivery microsphere carriers, shear-thinning gels, and precision injectors boost synovial retention, reduce post-procedure flare, and extend relief windows.

• Eco-forward formulations using low-residual crosslinkers, biobased excipients, and recyclable secondary packs satisfy hospital sustainability mandates while preserving biocompatibility.

• Smart, automated fill-finish with inline rheology, particle imaging, and sterile-barrier verification raises batch reproducibility, cuts deviations, and accelerates inspections.

• AI-guided stratification leveraging imaging, gait metrics, and EHR pain scores tunes dosing intervals, hyaluronan molecular weight, and collagen blends for individualized outcomes.

• Photo- and thermo-resilient matrices UV quenchers, antioxidants, light-temperature indicators protect viscoelasticity, lengthen shelf life, and stabilize performance through distribution.

Collagen and Hyaluronic Acid Intra-Articular Injections Market Growth Drivers:

• Advancements in Injectable Formulations are Driving the Collagen and Hyaluronic Acid Intra-Articular Injections Market Growth

Innovations in injectable preparation are one of the major factors increasing the growth of the collagen and hyaluronic acid intra-articular injections market. The combination therapies become promising with joint lubrication, tissue regeneration, and prolonged pain relief. These advancements are supporting patient outcomes and clinical uptake, creating a considerable impact on the collagen and hyaluronic acid intra-articular injections market share in developed and emerging healthcare markets.

For instance, in May 2025, Combination hyaluronic acid–collagen injections reached 22% of global approvals, up from 15% in 2023, significantly boosting market share and clinical adoption.

Collagen and Hyaluronic Acid Intra-Articular Injections Market Restraints:

• Regulatory and Reimbursement Challenges Are a Significant Restraint on the Collagen and Hyaluronic Acid Intra-Articular Injections Market Growth

Regulatory limitations and reimbursement issues are the major challenges for the collagen and hyaluronic acid intra-articular injections market. Different approval standards in different regions slow the translation and introduction of products, while inconsistent or limited insurance coverage hampers take-up by providers and patients alike. These barriers hinder market access, slow down the process of innovation, and affect the overall speed at which new and breakthrough therapies are delivered to the market.

For instance, in January 2024, the EMA delayed approval of two new hyaluronic acid–collagen injections, extending review timelines by 6–9 months due to stricter clinical evidence requirements.

Collagen and Hyaluronic Acid Intra-Articular Injections Market Segment Analysis

• By Product 

The hyaluronic acid injection is the dominant segment in the collagen and hyaluronic acid intra-articular injections market, with an 80.94% share in 2024, owing to its documented role in joint lubrication, anti-inflammatory effects, and preventing the progression of osteoarthritis. It is universally used in orthopedic clinical practice, FDA preferred, and by orthopedic specialists. Surging elderly population and preference for non-operative joint procedures are also driving its global supremacy.

The combination of hyaluronic acid and collagen segment is emerging as the fastest growing with a CAGR of 7.72% in the collagen and hyaluronic acid intra-articular injections market, owing to its combined effects, including hyaluronic acid lubricates, and collagen regenerates cartilage. The dual-action benefit, combined with increasing demand for improved joint preservation treatments and continued clinical inquiry, is driving increased acceptance among patients with end-stage joint disease.

• By Application

In 2024, Knee Osteoarthritis dominated the collagen and hyaluronic acid intra-articular injections industry with a 62.08% market share, and it is also emerging as the fastest growing segment over the forecast period, fueled by the high global incidence, particularly in elderly and obese subjects. The knee joint is subject to high weight loading and forces, explaining the higher prevalence of degenerative meniscal tears. Intra-articular injections provide localized pain relief and increased mobility, leading to robust clinical preference and high utilization amongst knee OA therapies.

• By Joint Type

Knee held a dominant collagen and hyaluronic acid intra-articular injections market share of 60.40% of the gene therapy starting materials industry in 2024, as it is the most vulnerable to osteoarthritis and degeneration. Demand is driven by a high mechanical load on knees and an aging population. These shots offer pain relief and increased lubrication and movement to the joints, and are the preferred non-surgical treatment for knee joint disorders.

Hip is emerging as the fastest growing segment in the collagen and hyaluronic acid intra-articular injections industry with the highest CAGR of 6.53%, owing to the increasing incidence of hip osteoarthritis and rising popularity of minimally invasive procedures. IIAs are in demand as patients avoid hip replacement procedures. Progress in imaging and injection technologies also helps to enhance accuracy and outcomes, driving market growth in hip applications.

• By Distribution Channel

Hospital pharmacies are the largest segment of the collagen and hyaluronic acid intra-articular injections industry, owing to their proximity to specialized care and modern therapeutic options, and a high case load. Known for quality care, germ-free spaces, and the instant effect of injectable treatments, these centers have a suggestion pin. The availability of healthcare personnel trained to administer the injection further guarantees its safety, contributing to patient preference and increasing the market share of hospital pharmacies in this market.

The online pharmacies segment is witnessing the highest growth in the Collagen and Hyaluronic Acid Intra-Articular Injections Market, due to the increasing digital penetration, convenience, and improving e-commerce infrastructure. They provide discreet sales, door-to-door delivery, and competitive prices. Increasing consumer confidence, integration with telehealth, and availability in remote areas are additional demand drivers, particularly for chronic joint conditions that require multiple injections, and contribute to a fast-growing segment.

Collagen and Hyaluronic Acid Intra-Articular Injections Market Regional Analysis

North America Collagen and Hyaluronic Acid Intra-Articular Injections Market Insights

In 2024, the North American region holds the largest market share of the collagen and hyaluronic acid intra-articular injections market and dominates the market with a 42.60% market share, owing to the sophisticated medical facilities, preponderance of osteoarthritis, and adoption of minimally invasive procedures. The region enjoys greater attention, the favour of reimbursement policies, and an aging population of senior citizens. Market domination is also being driven by key players, constant clinical trials, and FDA approvals. Furthermore, the increasing need for pain management treatment and personalized medicine is accelerating the dominance of the region in the market.

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U.S. Collagen and Hyaluronic Acid Intra-Articular Injections Market Insights

The U.S. collagen and hyaluronic acid intra-articular injections market was valued at USD 1.06 million in 2024 and is expected to reach USD 1.69 billion by 2032, growing at a CAGR of 6.03% over 2025-2032. The U.S. is dominant in the collagen and hyaluronic acid intra-articular injections market, driven by the relatively higher prevalence of osteoarthritis, well-developed healthcare infrastructure, high reimbursement rates, and a surge in the elderly population. Buoyed R&D spend and early uptake of new therapies are additional growth stimulants.

Europe Collagen and Hyaluronic Acid Intra-Articular Injections Market Insights

Europe is the second leading market for collagen and hyaluronic acid intra-articular injections, owing to the presence of developed healthcare systems, an increasing elderly population, and an increasing number of patients needing surgery for osteoarthritis and joint disorders. Rising prevalence of advanced intra-articular treatments, supportive regulatory umbrella, and investments in regenerative medicine continue to aid the market size. Furthermore, the strong presence of pharmaceutical companies and increasing reimbursement coverage increases the accessibility and market penetration in key European markets.

Asia-Pacific Collagen and Hyaluronic Acid Intra-Articular Injections Market Insights

Asia Pacific emerges as the fastest-growing region with the highest CAGR of 18.30%, as a result of demographic, socioeconomic, and health circumstances. There has been a drastic increase in the population of the aged in the region, particularly in Japan, China, and South Korea, which is one of the factors resulting in the growing incidence of both osteoarthritis and other joint-related disorders. Rapid urbanization, sedentary lifestyle, and increasing obesity rate are additional contributing factors to joint degeneration problems. Furthermore, developing healthcare infrastructure, growing awareness about intra-articular procedures, and rising disposable incomes are facilitating greater adoption of the advanced treatments. Government initiatives favouring orthopedic care and growing investments of various global pharmaceutical giants have also been driving the Asian-Pacific market, evolving it as a significant future market player.

Middle East & Africa Collagen and Hyaluronic Acid Intra-Articular Injections Market Insights

The Middle East & Africa have the least share in the global collagen and hyaluronic acid intra-articular injections market owing to poor healthcare facilities and low knowledge regarding advanced treatments of joints, and costly treatments. In addition, limited access to specialist care and lower reimbursement act against market penetration, which is leading to slower adoption than in more mature markets, such as North America and Europe.

Latin America Collagen and Hyaluronic Acid Intra-Articular Injections Market Insights

The collagen and hyaluronic acid intra-articular injections market in Latin America is expected to expand at a moderate growth rate due to increasing accessibility to health care services, surging incidence of osteoarthritis, and increasing public awareness about non-surgical treatments. Economic inequality and poor reimbursement, along with a lack of access to advanced therapies in rural areas, also retard growth, indicating that the region is some way off achieving the levels of North America or the Asia Pacific.

Collagen and Hyaluronic Acid Intra-Articular Injections Companies are:

Some of the Collagen and Hyaluronic Acid Intra-Articular Injections Market Companies

• Anika Therapeutics

• Fidia Farmaceutici

• Seikagaku Corp.

• Zimmer Biomet

• Bioventus

• Smith & Nephew

• Chugai Pharma

• LG Chem

• Sanofi

• TEOXANE SA

• BioPoly LLC

• Kolon Life Science

• Hyaltech

• Contura International

• Phibro Animal Health

• Allergan

• Regen Lab SA

• Xtant Medical

• TRB Chemedica

• Medline Industries

Competitive Landscape for the Collagen and Hyaluronic Acid Intra-Articular Injections Market:

Seikagaku Corporation, founded in 1947 and headquartered in Tokyo, Japan, specializes in glycoscience research and development. The company focuses on pharmaceuticals and medical devices, particularly hyaluronic acid-based products used in orthopedic, ophthalmic, and surgical fields, contributing to advancements in regenerative medicine and joint function improvement.

• In November 2024, Seikagaku launched a post-market surveillance program for ARTZ Dispo in Europe to strengthen long-term safety and effectiveness data, supporting broader regulatory compliance and physician confidence.

Zimmer Biomet, founded in 1927 and headquartered in Warsaw, Indiana, USA, is a global leader in musculoskeletal healthcare. The company develops orthopedic reconstructive products, sports medicine, spine, craniomaxillofacial, and dental solutions. Through innovation and advanced technologies, Zimmer Biomet enhances mobility, restores joint health, and improves quality of life for patients worldwide.

• In January 2024, Zimmer Biomet expanded Gel-One availability in the EU after favorable Phase IV trial results demonstrated long-term pain relief and improved joint function for osteoarthritis patients.