The Cell Dissociation Market size was estimated USD 352.83 million in 2023 and is expected to reach USD 975.82 million by 2031 at a CAGR of 13.56% during the forecast period of 2024-2031.
The cell dissociation process is known to use proteolytic enzymes to remove the adhering cell from the surface or substrate. Cell dissociation cushions feature collagenolytic and proteolytic properties that detach cell lines and tissues from the plastic or glass surfaces of the containers, increasing isolation efficacy with high cell practicality.
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Century Therapeutics and Bristol Myers Squibb announced a research collaboration and license agreement for up to four iPSC-derived initiatives for solid tumors and hematologic malignancies in September 2022. Furthermore, launching novel items provides attractive chances within the anticipated time. LevitasBio, for example, in November 2022, Optimized Tissue Dissociation Reagents release. Tissue dissociation kits from the company are specifically built for the LeviCell processes, enabling for end-to-end handling of a wide range of human and model tissue types such as heart, tumor, brain, liver, lung, and kidney.
DRIVERS
Rise in recombinant therapeutics sourced from mammalian cells
The share of recombinant medicines in the biopharmaceutical industry has increased significantly. More than 300 recombinant products had been launched as of June 2022, showing a significant transition toward mammalian-based treatments, which will account for over 67% of therapeutics in 2023. Cell culture products, such as cell dissociation, are essential in the development of mammalian-based recombinant therapies, accelerating business growth.
RESTRAIN
Cell-based research is expensive.
Isolation and purification of cell organelles need costly products, and automated/semi-automated benchtop tools are more expensive than older approaches. Despite the tremendous benefits provided by automated instruments, the high costs associated with these instruments may limit product adoption, thereby restraining market growth.
OPPORTUNITY
Non-enzymatic tissue dissociation advancement
Companies operating in the market are introducing novel and improved items to compete and create more income. To separate cells from primary tissues, most researchers in R&D institutes and biotechnology companies have relied on standard enzymatic dissociation tools. Although these classic enzymatic dissociation products have advantages, such as improved dissociation while conducting research, they can also be harmful and kill living cells. To address this issue and differentiate their product offers, some companies are launching non-enzymatic, non-cytotoxic solutions. Because of this benefit, the demand for non-enzymatic dissociation products is expanding among a variety of end users.
CHALLENGES
Dissociated cell culture has some limitations.
The main challenge of dissociated cultures is their low cell count in comparison to immortalized cell lines. This makes doing biochemical studies needing a large starting material volume challenging. Furthermore, most initial cell cultures are not homogenous, which makes cell dissociation investigations difficult. Neuronal cultures are frequently combinations of glia and neurons that respond to distinct neurotransmitters, making it challenging to identify an individual population of cells.
In response to the ongoing war in Ukraine, Danaher Corp. has banned the export of products to Russia, with the exception of products used for diagnosing and treating patients, as well as the production of vaccines and treatments. The Company incurred a $43 million pretax charge in the first quarter of 2022, principally attributable to the impairment of accounts receivable and inventories, as well as accruals for contractual commitments connected to Russian operations.
By Product
Enzymatic Dissociation
Trypsin
Collagenase
Elastase
Papain
Hyaluronidase
DNase
Others
Non-enzymatic dissociation
Instruments & Accessories
In 2023, Enzymatic Dissociation segment is expected to held the highest market share of 48.0% during the forecast period due to enzymatic dissociation is a technique that uses enzymes to breakdown the cut-up tissue fragments, freeing the cells from the tissue. Several types of enzymes are utilized in the dissociation process, and they can also be used in tandem. Enzymatic dissociations in general give a more effective and efficient approach of isolating mononuclear cells from the spinal cord and brain.
By Type
Tissue Dissociation
Cell Detachment
In 2023, the Tissue Dissociation segment is expected to dominate the market growth of 56.6% during the forecast period due to Factors such as biopharmaceutical and pharmaceutical firms' increased attention on the development of monoclonal antibodies and therapeutic customisation are expected to boost the expansion of this segment.
By End User
Pharmaceutical And Biotechnology Companies
Research & Academic Institutes
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In 2023, Pharmaceutical and Biotechnology Companies segment is expected to dominate the market growth of 71.7% during the forecast period to due to the cell dissociation enzymes are widely used in medications. Collagenase and trypsin are important enzymes in the preservation of solid tissues and adherent cells for culture and research. Furthermore, cell tissue disaggregation and dissociation represent the beginning of a wide range of research End Users, including cancer treatments, cell growth, and vaccine manufacture.
North America held a significant market share of around 37.3% in 2023 owing to the region's large proportion can be linked to the government's increased investment initiatives, the increased prevalence of chronic diseases like as cancer, as well as the existence of high-quality clinical and laboratory research infrastructure in the region. According to the Globocan study, roughly 2,281,659 new cancer cases were documented in the United States in 2022, with around 712,391 deaths. Thus, the increased frequency of chronic and infectious diseases, combined with a greater emphasis on cell-based treatments, is extending the market's potential prospects.
Asia-Pacific is witness to expand fastest CAGR rate during the forecast period due to the increasing demand for innovative medicines. Increasing government R&D investments and rapid infrastructure development are two other significant drivers driving regional market expansion. Furthermore, some area businesses are receiving financing to investigate treatments for chronic diseases such as cancer. For example, in June 2022, Immuneel Therapeutics received a budget of USD 15 million for developing affordable cell and gene therapy for cancer patients in India.
REGIONAL COVERAGE
North America
US
Canada
Mexico
Europe
Eastern Europe
Poland
Romania
Hungary
Turkey
Rest of Eastern Europe
Western Europe
Germany
France
UK
Italy
Spain
Netherlands
Switzerland
Austria
Rest of Western Europe
Asia Pacific
China
India
Japan
South Korea
Vietnam
Singapore
Australia
Rest of Asia Pacific
Middle East & Africa
Middle East
UAE
Egypt
Saudi Arabia
Qatar
Rest of Middle East
Africa
Nigeria
South Africa
Rest of Africa
Latin America
Brazil
Argentina
Colombia
Rest of Latin America
The major key players are Thermo Fisher Scientific, Danaher Corp., Merck KGaA, Sartorius AG, BD, PAN-Biotech, HiMedia Laboratories,STEMCELL Technologies, F. Hoffmann-La Roche Ltd., Agilent Technologies Inc., S2 Genomics, Inc., Miltenyi Biotec and Others.
In March 2023, Agilent Technologies Inc. has purchased the revolutionary electron capture dissociation (ECD) technology known as the ExD cell, a tiny equipment for mass spectrometers that allows biological researchers to manufacture biotherapeutic chemicals more quickly to treat disease. This is performed by breaking the chemical bonds of complex biomolecules more fully and precisely, allowing for the extraction of more thorough, exact, and detailed structural information from them.
In 2021, Danaher (Cytiva) collaborated with Diamyd Medical, who chose Cytiva's FlexFactory technology for producing precision medicine type 1 diabetes vaccines.
In 2021, Danaher (Cytiva) partnered with the Government of Telangana (India) to expand the biopharma business in India by opening new labs.
| Report Attributes | Details |
| Market Size in 2023 | US$ 352.83 Million |
| Market Size by 2031 | US$ 975.82 Million |
| CAGR | CAGR of 13.56% From 2024 to 2031 |
| Base Year | 2023 |
| Forecast Period | 2024-2031 |
| Historical Data | 2020-2022 |
| Report Scope & Coverage | Market Size, Segments Analysis, Competitive Landscape, Regional Analysis, DROC & SWOT Analysis, Forecast Outlook |
| Key Segments | • By Product (Enzymatic Dissociation, Non-enzymatic dissociation, Instruments & Accessories) • By Type (Tissue Dissociation, Cell Detachment) • By End User (Pharmaceutical and Biotechnology Companies, Research & Academic Institutes) |
| Regional Analysis/Coverage | North America (US, Canada, Mexico), Europe (Eastern Europe [Poland, Romania, Hungary, Turkey, Rest of Eastern Europe] Western Europe] Germany, France, UK, Italy, Spain, Netherlands, Switzerland, Austria, Rest of Western Europe]), Asia Pacific (China, India, Japan, South Korea, Vietnam, Singapore, Australia, Rest of Asia Pacific), Middle East & Africa (Middle East [UAE, Egypt, Saudi Arabia, Qatar, Rest of Middle East], Africa [Nigeria, South Africa, Rest of Africa], Latin America (Brazil, Argentina, Colombia Rest of Latin America) |
| Company Profiles | Thermo Fisher Scientific, Danaher Corp., Merck KGaA, Sartorius AG, BD, PAN-Biotech, HiMedia Laboratories,STEMCELL Technologies, F. Hoffmann-La Roche Ltd., Agilent Technologies Inc., S2 Genomics, Inc., Miltenyi Biotec |
| Key Drivers | • Rise in recombinant therapeutics sourced from mammalian cells |
| Market Challenges | • Dissociated cell culture has some limitations. |
Ans: Cell Dissociation Market is anticipated to expand by 13.56% from 2024 to 2031.
Ans: Cell Dissociation Market size was valued at USD 352.83 million in 2023.
Ans: USD 975.82 million is expected to grow by 2031.
Ans: Huge range of products available to help researchers, pharmaceutical companies, and clinicians in their efforts to study, manipulate, and utilize cells.
Ans: Limitations of Dissociated cell culture.
TABLE OF CONTENTS
1. Introduction
1.1 Market Definition
1.2 Scope
1.3 Research Assumptions
2. Industry Flowchart
3. Research Methodology
4. Market Dynamics
4.1 Drivers
4.2 Restraints
4.3 Opportunities
4.4 Challenges
5. Impact Analysis
5.1 Impact of Russia-Ukraine Crisis
5.2 Impact of Economic Slowdown on Major Countries
5.2.1 Introduction
5.2.2 United States
5.2.3 Canada
5.2.4 Germany
5.2.5 France
5.2.6 UK
5.2.7 China
5.2.8 Japan
5.2.9 South Korea
5.2.10 India
6. Value Chain Analysis
7. Porter’s 5 Forces Model
8. Pest Analysis
9. Cell Dissociation Market Segmentation, By Product
9.1 Introduction
9.3Enzymatic Dissociation
9.3.1 Trypsin
9.3.2 Collagenase
9.3.3 Elastase
9.3.4 Papain
9.3.5 Hyaluronidase
9.3.6 DNase
9.3.7 Others
9.4 Non-enzymatic dissociation
9.5 Types & Accessories
10. Cell Dissociation Market Segmentation, By Type
10.2 Trend Analysis
10.3 Tissue Dissociation
10.4 Cell Detachment
11. Cell Dissociation Market Segmentation, By End user
11.1 Introduction
11.3 Pharmaceutical And Biotechnology Companies
11.4 Research & Academic Institutes
12. Regional Analysis
12.1 Introduction
12.2 North America
12.2.1 Trend Analysis
12.2.2 North America Cell Dissociation Market by Country
12.2.3 North America Cell Dissociation Market By Product
12.2.4 North America Cell Dissociation Market By Type
12.2.5 North America Cell Dissociation Market By End user
12.2.6 USA
12.2.6.1 USA Cell Dissociation Market By Product
12.2.6.2 USA Cell Dissociation Market By Type
12.2.6.3 USA Cell Dissociation Market By End user
12.2.7 Canada
12.2.7.1 Canada Cell Dissociation Market By Product
12.2.7.2 Canada Cell Dissociation Market By Type
12.2.7.3 Canada Cell Dissociation Market By End user
12.2.8 Mexico
12.2.8.1 Mexico Cell Dissociation Market By Product
12.2.8.2 Mexico Cell Dissociation Market By Type
12.2.8.3 Mexico Cell Dissociation Market By End user
12.3 Europe
12.3.1 Trend Analysis
12.3.2 Eastern Europe
12.3.2.1 Eastern Europe Cell Dissociation Market by Country
12.3.2.2 Eastern Europe Cell Dissociation Market By Product
12.3.2.3 Eastern Europe Cell Dissociation Market By Type
12.3.2.4 Eastern Europe Cell Dissociation Market By End user
12.3.2.5 Poland
12.3.2.5.1 Poland Cell Dissociation Market By Product
12.3.2.5.2 Poland Cell Dissociation Market By Type
12.3.2.5.3 Poland Cell Dissociation Market By End user
12.3.2.6 Romania
12.3.2.6.1 Romania Cell Dissociation Market By Product
12.3.2.6.2 Romania Cell Dissociation Market By Type
12.3.2.6.4 Romania Cell Dissociation Market By End user
12.3.2.7 Hungary
12.3.2.7.1 Hungary Cell Dissociation Market By Product
12.3.2.7.2 Hungary Cell Dissociation Market By Type
12.3.2.7.3 Hungary Cell Dissociation Market By End user
12.3.2.8 Turkey
12.3.2.8.1 Turkey Cell Dissociation Market By Product
12.3.2.8.2 Turkey Cell Dissociation Market By Type
12.3.2.8.3 Turkey Cell Dissociation Market By End user
12.3.2.9 Rest of Eastern Europe
12.3.2.9.1 Rest of Eastern Europe Cell Dissociation Market By Product
12.3.2.9.2 Rest of Eastern Europe Cell Dissociation Market By Type
12.3.2.9.3 Rest of Eastern Europe Cell Dissociation Market By End user
12.3.3 Western Europe
12.3.3.1 Western Europe Cell Dissociation Market by Country
12.3.3.2 Western Europe Cell Dissociation Market By Product
12.3.3.3 Western Europe Cell Dissociation Market By Type
12.3.3.4 Western Europe Cell Dissociation Market By End user
12.3.3.5 Germany
12.3.3.5.1 Germany Cell Dissociation Market By Product
12.3.3.5.2 Germany Cell Dissociation Market By Type
12.3.3.5.3 Germany Cell Dissociation Market By End user
12.3.3.6 France
12.3.3.6.1 France Cell Dissociation Market By Product
12.3.3.6.2 France Cell Dissociation Market By Type
12.3.3.6.3 France Cell Dissociation Market By End user
12.3.3.7 UK
12.3.3.7.1 UK Cell Dissociation Market By Product
12.3.3.7.2 UK Cell Dissociation Market By Type
12.3.3.7.3 UK Cell Dissociation Market By End user
12.3.3.8 Italy
12.3.3.8.1 Italy Cell Dissociation Market By Product
12.3.3.8.2 Italy Cell Dissociation Market By Type
12.3.3.8.3 Italy Cell Dissociation Market By End user
12.3.3.9 Spain
12.3.3.9.1 Spain Cell Dissociation Market By Product
12.3.3.9.2 Spain Cell Dissociation Market By Type
12.3.3.9.3 Spain Cell Dissociation Market By End user
12.3.3.10 Netherlands
12.3.3.10.1 Netherlands Cell Dissociation Market By Product
12.3.3.10.2 Netherlands Cell Dissociation Market By Type
12.3.3.10.3 Netherlands Cell Dissociation Market By End user
12.3.3.11 Switzerland
12.3.3.11.1 Switzerland Cell Dissociation Market By Product
12.3.3.11.2 Switzerland Cell Dissociation Market By Type
12.3.3.11.3 Switzerland Cell Dissociation Market By End user
12.3.3.1.12 Austria
12.3.3.12.1 Austria Cell Dissociation Market By Product
12.3.3.12.2 Austria Cell Dissociation Market By Type
12.3.3.12.3 Austria Cell Dissociation Market By End user
12.3.3.13 Rest of Western Europe
12.3.3.13.1 Rest of Western Europe Cell Dissociation Market By Product
12.3.3.13.2 Rest of Western Europe Cell Dissociation Market By Type
12.3.3.13.3 Rest of Western Europe Cell Dissociation Market By End user
12.4 Asia-Pacific
12.4.1 Trend Analysis
12.4.2 Asia-Pacific Cell Dissociation Market by Country
12.4.3 Asia-Pacific Cell Dissociation Market By Product
12.4.4 Asia-Pacific Cell Dissociation Market By Type
12.4.5 Asia-Pacific Cell Dissociation Market By End user
12.4.6 China
12.4.6.1 China Cell Dissociation Market By Product
12.4.6.2 China Cell Dissociation Market By Type
12.4.6.3 China Cell Dissociation Market By End user
12.4.7 India
12.4.7.1 India Cell Dissociation Market By Product
12.4.7.2 India Cell Dissociation Market By Type
12.4.7.3 India Cell Dissociation Market By End user
12.4.8 Japan
12.4.8.1 Japan Cell Dissociation Market By Product
12.4.8.2 Japan Cell Dissociation Market By Type
12.4.8.3 Japan Cell Dissociation Market By End user
12.4.9 South Korea
12.4.9.1 South Korea Cell Dissociation Market By Product
12.4.9.2 South Korea Cell Dissociation Market By Type
12.4.9.3 South Korea Cell Dissociation Market By End user
12.4.10 Vietnam
12.4.10.1 Vietnam Cell Dissociation Market By Product
12.4.10.2 Vietnam Cell Dissociation Market By Type
12.4.10.3 Vietnam Cell Dissociation Market By End user
12.4.11 Singapore
12.4.11.1 Singapore Cell Dissociation Market By Product
12.4.11.2 Singapore Cell Dissociation Market By Type
12.4.11.3 Singapore Cell Dissociation Market By End user
12.4.12 Australia
12.4.12.1 Australia Cell Dissociation Market By Product
12.4.12.2 Australia Cell Dissociation Market By Type
12.4.12.3 Australia Cell Dissociation Market By End user
12.4.13 Rest of Asia-Pacific
12.4.13.1 Rest of Asia-Pacific Cell Dissociation Market By Product
12.4.13.2 Rest of Asia-Pacific Cell Dissociation Market By Type
12.4.13.3 Rest of Asia-Pacific Cell Dissociation Market By End user
12.5 Middle East & Africa
12.5.1 Trend Analysis
12.5.2 Middle East
12.5.2.1 Middle East Cell Dissociation Market by Country
12.5.2.2 Middle East Cell Dissociation Market By Product
12.5.2.3 Middle East Cell Dissociation Market By Type
12.5.2.4 Middle East Cell Dissociation Market By End user
12.5.2.5 UAE
12.5.2.5.1 UAE Cell Dissociation Market By Product
12.5.2.5.2 UAE Cell Dissociation Market By Type
12.5.2.5.3 UAE Cell Dissociation Market By End user
12.5.2.6 Egypt
12.5.2.6.1 Egypt Cell Dissociation Market By Product
12.5.2.6.2 Egypt Cell Dissociation Market By Type
12.5.2.6.3 Egypt Cell Dissociation Market By End user
12.5.2.7 Saudi Arabia
12.5.2.7.1 Saudi Arabia Cell Dissociation Market By Product
12.5.2.7.2 Saudi Arabia Cell Dissociation Market By Type
12.5.2.7.3 Saudi Arabia Cell Dissociation Market By End user
12.5.2.8 Qatar
12.5.2.8.1 Qatar Cell Dissociation Market By Product
12.5.2.8.2 Qatar Cell Dissociation Market By Type
12.5.2.8.3 Qatar Cell Dissociation Market By End user
12.5.2.9 Rest of Middle East
12.5.2.9.1 Rest of Middle East Cell Dissociation Market By Product
12.5.2.9.2 Rest of Middle East Cell Dissociation Market By Type
12.5.2.9.3 Rest of Middle East Cell Dissociation Market By End user
12.5.3 Africa
12.5.3.1 Africa Cell Dissociation Market by Country
12.5.3.2 Africa Cell Dissociation Market By Product
12.5.3.3 Africa Cell Dissociation Market By Type
12.5.3.4 Africa Cell Dissociation Market By End user
12.5.3.5 Nigeria
12.5.3.5.1 Nigeria Cell Dissociation Market By Product
12.5.3.5.2 Nigeria Cell Dissociation Market By Type
12.5.3.5.3 Nigeria Cell Dissociation Market By End user
12.5.3.6 South Africa
12.5.3.6.1 South Africa Cell Dissociation Market By Product
12.5.3.6.2 South Africa Cell Dissociation Market By Type
12.5.3.6.3 South Africa Cell Dissociation Market By End user
12.5.3.7 Rest of Africa
12.5.3.7.1 Rest of Africa Cell Dissociation Market By Product
12.5.3.7.2 Rest of Africa Cell Dissociation Market By Type
12.5.3.7.3 Rest of Africa Cell Dissociation Market By End user
12.6 Latin America
12.6.1 Trend Analysis
12.6.2 Latin America Cell Dissociation Market by country
12.6.3 Latin America Cell Dissociation Market By Product
12.6.4 Latin America Cell Dissociation Market By Type
12.6.5 Latin America Cell Dissociation Market By End user
12.6.6 Brazil
12.6.6.1 Brazil Cell Dissociation Market By Product
12.6.6.2 Brazil Cell Dissociation Market By Type
12.6.6.3 Brazil Cell Dissociation Market By End user
12.6.7 Argentina
12.6.7.1 Argentina Cell Dissociation Market By Product
12.6.7.2 Argentina Cell Dissociation Market By Type
12.6.7.3 Argentina Cell Dissociation Market By End user
12.6.8 Colombia
12.6.8.1 Colombia Cell Dissociation Market By Product
12.6.8.2 Colombia Cell Dissociation Market By Type
12.6.8.3 Colombia Cell Dissociation Market By End user
12.6.9 Rest of Latin America
12.6.9.1 Rest of Latin America Cell Dissociation Market By Product
12.6.9.2 Rest of Latin America Cell Dissociation Market By Type
12.6.9.3 Rest of Latin America Cell Dissociation Market By End user
13. Company Profiles
13.1 Thermo Fisher Scientific
13.1.1 Company Overview
13.1.2 Financial
13.1.3 Product/ Services Offered
13.1.4 SWOT Analysis
13.1.5 The SNS View
13.2 Danaher Corp.
13.2.1 Company Overview
13.2.2 Financial
13.2.3 Product / Services Offered
13.2.4 SWOT Analysis
13.2.5 The SNS View
13.3 Vitrolife
13.3.1 Company Overview
13.3.2 Financial
13.3.3 Product / Services Offered
13.3.4 SWOT Analysis
13.3.5 The SNS View
13.4 Merck KGaA
13.4.1 Company Overview
13.4.2 Financial
13.4.3 Product / Services Offered
13.4.4 SWOT Analysis
13.4.5 The SNS View
13.5 Sartorius AG
13.5.1 Company Overview
13.5.2 Financial
13.5.3 Product/ Services Offered
13.5.4 SWOT Analysis
13.5.5 The SNS View
13.6 PAN-Biotec
13.6.1 Company Overview
13.6.2 Financial
13.6.3 Product/ Services Offered
13.6.4 SWOT Analysis
13.6.5 The SNS View
13.7 HiMedia Laboratories
13.7.1 Company Overview
13.7.2 Financial
13.7.3 Product/ Services Offered
13.7.4 SWOT Analysis
13.7.5 The SNS View
13.8.1 Company Overview
13.8.2 Financial
13.8.3 Product/ Services Offered
13.8.4 SWOT Analysis
13.8.5 The SNS View
13.9 F. Hoffmann-La Roche Ltd.
13.9.1 Company Overview
13.9.2 Financial
13.9.3 Product/ Services Offered
13.9.4 SWOT Analysis
13.9.5 The SNS View
13.10 Agilent Technologies Inc.
13.10.1 Company Overview
13.10.2 Financial
13.10.3 Product/ Services Offered
13.10.4 SWOT Analysis
13.10.5 The SNS View
14. Competitive Landscape
14.1 Competitive Benchmarking
14.2 Market Share Analysis
14.3 Recent Developments
14.3.1 Industry News
14.3.2 Company News
14.3.3 Mergers & Acquisitions
15. Use Case and Best Practices
16. Conclusion
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