The Bone Graft and Substitutes Market size was valued at US$ 2.95 Billion in 2023 and is projected to reach US$ 4.88 Billion by 2031, with a growing CAGR of 6.5% over the forecast period 2024-2031.
The Bone Graft and Substitutes Market is booming as surgeons are favouring synthetic substitutes for their safety, compatibility, and ability to promote bone healing. Regulatory approvals for these innovative products are on the rise. Additionally, the growing popularity of minimally invasive surgeries for fractures, facial injuries, and sports injuries is propelling the demand for bone graft alternatives. An aging population with increasing bone issues further fuels market growth. Advancements in medical technology are leading to the development of superior bone graft products, improving surgical outcomes and patient safety. Supportive regulatory frameworks and ongoing efforts to create even better products are paving the way for further market expansion.
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Extending pace of road wounds and joint issues
The pace of street wounds is on the ascent. For example, as per the WHO, around 20 to 50 million individuals experience non-lethal wounds, and roughly 1.35 million individuals kick the bucket because of street mishaps consistently. In addition, as per the National Trauma Institute, 2014, the financial weight because of injury cases has expanded to USD 671 billion, including medical care expenses and lost efficiency costs. Bone graft has various applications in fixing wounds and infections. It could be utilized on account of different or complex cracks or those that don't recuperate well after starting treatment. It is likewise utilized for a combination that assists two bones with recuperating in a sick joint. The Combination is most frequently done on the spine.
Improvement of biocompatible produced bone associations
Extended interest in dental bone associations
The Significant expense of the medical procedures
The expense of a bone graft fluctuates generally relying upon the circumstance and the state of the patient. For instance, basic bone uniting for dental purposes utilizing engineered bone will cost anyplace from USD 300 to USD 800 for a solitary embed district. At the point when a patient's bone material is obtained from various pieces of the body for bone graft activity, hospitalization is required, which builds the expense. This type of graft additionally requires the administration of a muscular specialist and an anesthesiologist, bringing about a dental bone graft cost of USD 2,500 to USD 3,500.
Chance and entanglements from bone graft methods
High interest in the muscular consideration area
Thorough and practically identical appraisals of well-being spending in every nation are a critical contribution to well-being strategy and in proper order. They are important to help the accomplishments of public and global wellbeing objectives. On February 20, 2019, the WHO delivered another report on worldwide well-being consumption, as indicated by which the worldwide spending on well-being in low-and center pay nations expanded by 6%and in top-level salary nations by 4%. State-run administrations represent under 40%of essential medical services spending. Many organizations are grafting the area in light of the great market and an open door. Existing players are burning through huge amounts of cash on research and improvement to add cutting-edge innovations to their portfolios and keep up with their piece of the pie.
Risk of Complications
As with any medical procedure, bone graft surgeries using substitutes carry some risks of complications such as infection, rejection, or nerve damage.
Strict regulations imposed by governing bodies like the FDA can lead to lengthy and costly approval processes for new bone graft substitutes
The Russia Ukraine war disrupts the promising growth of the Bone Graft and Substitutes Market. This disruption affects various procedures, including craniomaxillofacial, dental, foot & ankle, joint reconstruction, long bone, and spinal fusion surgeries like the war has crippled global supply chains, making it difficult to acquire raw materials and finished bone graft substitutes. This translates to potential shortages and inflated prices, hindering surgeries across all these applications. Ukraine's healthcare system, overwhelmed by treating war injuries, has diverted resources away from elective procedures like those requiring bone grafts. This prioritization is likely to most significantly impact complex surgeries like craniomaxillofacial and spinal fusion procedures. The war's economic fallout, with rising inflation and fuel prices, might lead to decreased healthcare spending. This could make bone graft surgeries less affordable, particularly in regions heavily impacted by the economic crisis. Finally, ongoing clinical trials for new bone graft substitutes might face delays due to the war. This could hinder advancements in this field and delay the introduction of potentially life-saving technologies.
The Bone Graft and Substitutes Market, despite its promising growth trajectory, faces disturbance due to economic downturns. These slowdowns can impact a wide range of procedures, including craniomaxillofacial, dental, foot & ankle, joint reconstruction, long bone, and spinal fusion surgeries. The impact of an economic slowdown might not be uniform across all procedures. Craniomaxillofacial and spinal fusion surgeries, often deemed more essential due to potential functional limitations, might see a smaller decline compared to elective procedures. However, a prolonged economic downturn could lead to a talent drain in healthcare, with medical professionals seeking more stable job opportunities. This potential shortage of skilled surgeons qualified for bone graft surgeries could further restrict patient access to these procedures in the long run.
Allograft
Demineralized Bone Matrix
Others
Synthetic
Ceramics
HAP
β-TCP
α-TCP
Bi-phasic Calcium Phosphates (BCP)
Others
Composites
Polymers
Bone Morphogenic Proteins (BMP)
Allografts (donated human bone) currently holding the biggest share. These are popular due to their ability to promote bone growth (osteoconductivity) and provide immediate structure. However, synthetic bone grafts are expected to see the fastest growth. Synthetics offer lower disease transmission risk, better biocompatibility, and are generally more accepted by patients. This segment is further fueled by the rising burden of bone disorders and increasing demand in developed countries.
Craniomaxillofacial
Dental
Foot & Ankle
Joint Reconstruction
Long Bone
Spinal Fusion
Spinal fusion procedures currently dominate the bone graft market due to their use in treating spinal conditions common among the growing elderly population. However, dental applications are expected to see the fastest growth. This is driven by the increasing popularity of dental implants and bone regeneration techniques, which rely on bone grafts for successful outcomes.
North America overwhelmed the market with more than 40% portion of the worldwide income in 2023. Developing mindfulness connected with the economically available imaginative items, the openness of an advanced medical care structure, and higher medical services use of 16.9% in 2018 is the significant angles adding to the local market development. The market in the U.S. is driving the North American as well as worldwide market by creating the most extreme interest for bone grafts and substitutes on account of the developing number of injury-related wounds as well as instances of muscular infection.
Asia Pacific is assessed to observe rewarding development during the gauge time frame. This development can be ascribed to rising clinical the travel industry and ideal government drives. Then again, tough administrative rules limit the reception in a couple of countries. For example, in South Korea, the item must be supported prior to advertising by the Korean Food and Drug Administration (KFDA). In Australia, the items are directed by the Therapeutic Goods Administration (TGA). The tough administrative viewpoint in Japan confines the passage of unfamiliar players into the country. However, with the most recent endorsement of DBM in Japan in 2019, the allograft market is set to keep worthwhile development in the Asia Pacific over the course of the following 10 years.
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North America
US
Canada
Mexico
Europe
Eastern Europe
Poland
Romania
Hungary
Turkey
Rest of Eastern Europe
Western Europe
Germany
France
UK
Italy
Spain
Netherlands
Switzerland
Austria
Rest of Western Europe
Asia Pacific
China
India
Japan
South Korea
Vietnam
Singapore
Australia
Rest of Asia Pacific
Middle East & Africa
Middle East
UAE
Egypt
Saudi Arabia
Qatar
Rest of the Middle East
Africa
Nigeria
South Africa
Rest of Africa
Latin America
Brazil
Argentina
Colombia
Rest of Latin America
The major players are AlloSource, Baxter International Inc., TBF, Johnson & Johnson (DePuy Synthes), Medtronic Plc., Biobank, NuVasive Inc., Stryker Corporation, Xtant Medical Holdings Inc., Smith + Nephew, Zimmer Biomet Holdings Inc., OST Laboratories, Orthofix US LLC, Geistlich Pharma AG and Other Players.
October 2023: Orthofix Medical Inc. launched OsteoCoveTM, a novel FDA-approved synthetic bone graft for various orthopedic and spine surgeries. This innovative product comes in putty and strip forms and boasts exceptional bone-forming properties.
February 2023: NuVasive, Inc. secured FDA approval for their Modulus Cervical interbody implant, further expanding their C360 product line.
June 2022: Medtronic received FDA approval for a ligament-augmenting implant, solidifying their position in the spine surgery market.
March 2022: Zimmer Biomet partnered with Biocomposites to distribute their genex bone graft substitutes.
| Report Attributes | Details |
|---|---|
| Market Size in 2023 | US$ 2.95 Billion |
| Market Size by 2031 | US$ 4.88 Billion |
| CAGR | CAGR of 6.5% From 2024 to 2031 |
| Base Year | 2023 |
| Forecast Period | 2024-2031 |
| Historical Data | 2020-2022 |
| Report Scope & Coverage | Market Size, Segments Analysis, Competitive Landscape, Regional Analysis, DROC & SWOT Analysis, Forecast Outlook |
| Key Segments |
|
| Regional Analysis/Coverage | North America (US, Canada, Mexico), Europe (Eastern Europe [Poland, Romania, Hungary, Turkey, Rest of Eastern Europe] Western Europe] Germany, France, UK, Italy, Spain, Netherlands, Switzerland, Austria, Rest of Western Europe]), Asia Pacific (China, India, Japan, South Korea, Vietnam, Singapore, Australia, Rest of Asia Pacific), Middle East & Africa (Middle East [UAE, Egypt, Saudi Arabia, Qatar, Rest of Middle East], Africa [Nigeria, South Africa, Rest of Africa], Latin America (Brazil, Argentina, Colombia, Rest of Latin America) |
| Company Profiles | AlloSource, Baxter International Inc., TBF, Johnson & Johnson (DePuy Synthes), Medtronic Plc., Biobank, NuVasive Inc., Stryker Corporation, Xtant Medical Holdings Inc., Smith + Nephew, Zimmer Biomet Holdings Inc., OST Laboratories, Orthofix US LLC, Geistlich Pharma AG |
| DRIVING FACTORS |
|
| Restraints |
|
Ans:- The Bone Graft and Substitutes Market was valued at USD 2.95 Bn by 2023.
Ans: The Bone Graft and Substitutes Market is growing at a CAGR of 6.5% over the forecast period 2024-2031.
North America was the greatest revenue contributor in the bone graft and alternatives market.
The forecast period for the Bone Graft and Substitutes Market is 2024 to 2031.
. Key Stakeholders Considered in the study:
Raw material vendors
Distributors/traders/wholesalers/suppliers
Regulatory authorities, including government agencies and NGO
Commercial research & development (R&D) institutions
Importers and exporters
Government organizations, research organizations, and consulting firms
Trade/Industrial associations
End-use industries are the stake holder of this report
Table of Contents
1. Introduction
1.1 Market Definition
1.2 Scope
1.3 Research Assumptions
2. Industry Flowchart
3. Research Methodology
4. Market Dynamics
4.1 Drivers
4.2 Restraints
4.3 Opportunities
4.4 Challenges
5. Impact Analysis
5.1 Impact Of Russia Ukraine Crisis
5.2 Impact of Economic Slowdown on Major Countries
5.2.1 Introduction
5.2.2 United States
5.2.3 Canada
5.2.4 Germany
5.2.5 France
5.2.6 UK
5.2.7 China
5.2.8 Japan
5.2.9 South Korea
5.2.10 India
6. Value Chain Analysis
7. Porter’s 5 Forces Model
8. Pest Analysis
9. Bone Graft and Substitutes Market Segmentation, By Material Type
9.1 Introduction
9.2 Trend Analysis
9.3 Allograft
9.3.1 Demineralized Bone Matrix
9.3.2 Others
9.4 Synthetic
9.4.1 Ceramics
9.4.1.1 HAP
9.4.1.2 β-TCP
9.4.1.3 α-TCP
9.4.1.4 Bi-phasic Calcium Phosphates (BCP)
9.4.1.5 Others
9.4.2 Composites
9.4.3 Polymers
9.4.4 Bone Morphogenic Proteins (BMP)
10. Bone Graft and Substitutes Market Segmentation, By Application
10.1 Introduction
10.2 Trend Analysis
10.3 Craniomaxillofacial
10.4 Dental
10.5 Foot & Ankle
10.6 Joint Reconstruction
10.7 Long Bone
10.8 Spinal Fusion
11. Regional Analysis
11.1 Introduction
11.2 North America
11.2.1 Trend Analysis
11.2.2 North America Bone Graft and Substitutes Market by Country
11.2.3 North America Bone Graft and Substitutes Market By Material Type
11.2.4 North America Bone Graft and Substitutes Market By Application
11.2.5 USA
11.2.5.1 USA Bone Graft and Substitutes Market By Material Type
11.2.5.2 USA Bone Graft and Substitutes Market By Application
11.2.6 Canada
11.2.6.1 Canada Bone Graft and Substitutes Market By Material Type
11.2.6.2 Canada Bone Graft and Substitutes Market By Application
11.2.7 Mexico
11.2.7.1 Mexico Bone Graft and Substitutes Market By Material Type
11.2.7.2 Mexico Bone Graft and Substitutes Market By Application
11.3 Europe
11.3.1 Trend Analysis
11.3.2 Eastern Europe
11.3.2.1 Eastern Europe Bone Graft and Substitutes Market by Country
11.3.2.2 Eastern Europe Bone Graft and Substitutes Market By Material Type
11.3.2.3 Eastern Europe Bone Graft and Substitutes Market By Application
11.3.2.4 Poland
11.3.2.4.1 Poland Bone Graft and Substitutes Market By Material Type
11.3.2.4.2 Poland Bone Graft and Substitutes Market By Application
11.3.2.5 Romania
11.3.2.5.1 Romania Bone Graft and Substitutes Market By Material Type
11.3.2.5.2 Romania Bone Graft and Substitutes Market By Application
11.3.2.6 Hungary
11.3.2.6.1 Hungary Bone Graft and Substitutes Market By Material Type
11.3.2.6.2 Hungary Bone Graft and Substitutes Market By Application
11.3.2.7 Turkey
11.3.2.7.1 Turkey Bone Graft and Substitutes Market By Material Type
11.3.2.7.2 Turkey Bone Graft and Substitutes Market By Application
11.3.2.8 Rest of Eastern Europe
11.3.2.8.1 Rest of Eastern Europe Bone Graft and Substitutes Market By Material Type
11.3.2.8.2 Rest of Eastern Europe Bone Graft and Substitutes Market By Application
11.3.3 Western Europe
11.3.3.1 Western Europe Bone Graft and Substitutes Market by Country
11.3.3.2 Western Europe Bone Graft and Substitutes Market By Material Type
11.3.3.3 Western Europe Bone Graft and Substitutes Market By Application
11.3.3.4 Germany
11.3.3.4.1 Germany Bone Graft and Substitutes Market By Material Type
11.3.3.4.2 Germany Bone Graft and Substitutes Market By Application
11.3.3.5 France
11.3.3.5.1 France Bone Graft and Substitutes Market By Material Type
11.3.3.5.2 France Bone Graft and Substitutes Market By Application
11.3.3.6 UK
11.3.3.6.1 UK Bone Graft and Substitutes Market By Material Type
11.3.3.6.2 UK Bone Graft and Substitutes Market By Application
11.3.3.7 Italy
11.3.3.7.1 Italy Bone Graft and Substitutes Market By Material Type
11.3.3.7.2 Italy Bone Graft and Substitutes Market By Application
11.3.3.8 Spain
11.3.3.8.1 Spain Bone Graft and Substitutes Market By Material Type
11.3.3.8.2 Spain Bone Graft and Substitutes Market By Application
11.3.3.9 Netherlands
11.3.3.9.1 Netherlands Bone Graft and Substitutes Market By Material Type
11.3.3.9.2 Netherlands Bone Graft and Substitutes Market By Application
11.3.3.10 Switzerland
11.3.3.10.1 Switzerland Bone Graft and Substitutes Market By Material Type
11.3.3.10.2 Switzerland Bone Graft and Substitutes Market By Application
11.3.3.11 Austria
11.3.3.11.1 Austria Bone Graft and Substitutes Market By Material Type
11.3.3.11.2 Austria Bone Graft and Substitutes Market By Application
11.3.3.12 Rest of Western Europe
11.3.3.12.1 Rest of Western Europe Bone Graft and Substitutes Market By Material Type
11.3.2.12.2 Rest of Western Europe Bone Graft and Substitutes Market By Application
11.4 Asia-Pacific
11.4.1 Trend Analysis
11.4.2 Asia Pacific Bone Graft and Substitutes Market by Country
11.4.3 Asia Pacific Bone Graft and Substitutes Market By Material Type
11.4.4 Asia Pacific Bone Graft and Substitutes Market By Application
11.4.5 China
11.4.5.1 China Bone Graft and Substitutes Market By Material Type
11.4.5.2 China Bone Graft and Substitutes Market By Application
11.4.6 India
11.4.6.1 India Bone Graft and Substitutes Market By Material Type
11.4.6.2 India Bone Graft and Substitutes Market By Application
11.4.7 Japan
11.4.7.1 Japan Bone Graft and Substitutes Market By Material Type
11.4.7.2 Japan Bone Graft and Substitutes Market By Application
11.4.8 South Korea
11.4.8.1 South Korea Bone Graft and Substitutes Market By Material Type
11.4.8.2 South Korea Bone Graft and Substitutes Market By Application
11.4.9 Vietnam
11.4.9.1 Vietnam Bone Graft and Substitutes Market By Material Type
11.4.9.2 Vietnam Bone Graft and Substitutes Market By Application
11.4.10 Singapore
11.4.10.1 Singapore Bone Graft and Substitutes Market By Material Type
11.4.10.2 Singapore Bone Graft and Substitutes Market By Application
11.4.11 Australia
11.4.11.1 Australia Bone Graft and Substitutes Market By Material Type
11.4.11.2 Australia Bone Graft and Substitutes Market By Application
11.4.12 Rest of Asia-Pacific
11.4.12.1 Rest of Asia-Pacific Bone Graft and Substitutes Market By Material Type
11.4.12.2 Rest of Asia-Pacific Bone Graft and Substitutes Market By Application
11.5 Middle East & Africa
11.5.1 Trend Analysis
11.5.2 Middle East
11.5.2.1 Middle East Bone Graft and Substitutes Market by Country
11.5.2.2 Middle East Bone Graft and Substitutes Market By Material Type
11.5.2.3 Middle East Bone Graft and Substitutes Market By Application
11.5.2.4 UAE
11.5.2.4.1 UAE Bone Graft and Substitutes Market By Material Type
11.5.2.4.2 UAE Bone Graft and Substitutes Market By Application
11.5.2.5 Egypt
11.5.2.5.1 Egypt Bone Graft and Substitutes Market By Material Type
11.5.2.5.2 Egypt Bone Graft and Substitutes Market By Application
11.5.2.6 Saudi Arabia
11.5.2.6.1 Saudi Arabia Bone Graft and Substitutes Market By Material Type
11.5.2.6.2 Saudi Arabia Bone Graft and Substitutes Market By Application
11.5.2.7 Qatar
11.5.2.7.1 Qatar Bone Graft and Substitutes Market By Material Type
11.5.2.7.2 Qatar Bone Graft and Substitutes Market By Application
11.5.2.8 Rest of Middle East
11.5.2.8.1 Rest of Middle East Bone Graft and Substitutes Market By Material Type
11.5.2.8.2 Rest of Middle East Bone Graft and Substitutes Market By Application
11.5.3 Africa
11.5.3.1 Africa Bone Graft and Substitutes Market by Country
11.5.3.2 Africa Bone Graft and Substitutes Market By Material Type
11.5.3.3 Africa Bone Graft and Substitutes Market By Application
11.5.2.4 Nigeria
11.5.2.4.1 Nigeria Bone Graft and Substitutes Market By Material Type
11.5.2.4.2 Nigeria Bone Graft and Substitutes Market By Application
11.5.2.5 South Africa
11.5.2.5.1 South Africa Bone Graft and Substitutes Market By Material Type
11.5.2.5.2 South Africa Bone Graft and Substitutes Market By Application
11.5.2.6 Rest of Africa
11.5.2.6.1 Rest of Africa Bone Graft and Substitutes Market By Material Type
11.5.2.6.2 Rest of Africa Bone Graft and Substitutes Market By Application
11.6 Latin America
11.6.1 Trend Analysis
11.6.2 Latin America Bone Graft and Substitutes Market by Country
11.6.3 Latin America Bone Graft and Substitutes Market By Material Type
11.6.4 Latin America Bone Graft and Substitutes Market By Application
11.6.5 Brazil
11.6.5.1 Brazil Bone Graft and Substitutes Market By Material Type
11.6.5.2 Brazil Bone Graft and Substitutes Market By Application
11.6.6 Argentina
11.6.6.1 Argentina Bone Graft and Substitutes Market By Material Type
11.6.6.2 Argentina Bone Graft and Substitutes Market By Application
11.6.7 Colombia
11.6.7.1 Colombia Bone Graft and Substitutes Market By Material Type
11.6.7.2 Colombia Bone Graft and Substitutes Market By Application
11.6.8 Rest of Latin America
11.6.8.1 Rest of Latin America Bone Graft and Substitutes Market By Material Type
11.6.8.2 Rest of Latin America Bone Graft and Substitutes Market By Application
12. Company Profiles
12.1 AlloSource
12.1.1 Company Overview
12.1.2 Financial
12.1.3 Products/ Services Offered
12.1.4 SWOT Analysis
12.1.5 The SNS View
12.2 Baxter International Inc.
12.2.1 Company Overview
12.2.2 Financial
12.2.3 Products/ Services Offered
12.2.4 SWOT Analysis
12.2.5 The SNS View
12.3 TBF
12.3.1 Company Overview
12.3.2 Financial
12.3.3 Products/ Services Offered
12.3.4 SWOT Analysis
12.3.5 The SNS View
12.4 Johnson & Johnson (DePuy Synthesis)
12.4.1 Company Overview
12.4.2 Financial
12.4.3 Products/ Services Offered
12.4.4 SWOT Analysis
12.4.5 The SNS View
12.5 Medtronic Plc.
12.5.1 Company Overview
12.5.2 Financial
12.5.3 Products/ Services Offered
12.5.4 SWOT Analysis
12.5.5 The SNS View
12.6 Biobank
12.6.1 Company Overview
12.6.2 Financial
12.6.3 Products/ Services Offered
12.6.4 SWOT Analysis
12.6.5 The SNS View
12.7 NuVasive Inc.
12.7.1 Company Overview
12.7.2 Financial
12.7.3 Products/ Services Offered
12.7.4 SWOT Analysis
12.7.5 The SNS View
12.8 Stryker Corporation
12.8.1 Company Overview
12.8.2 Financial
12.8.3 Products/ Services Offered
12.8.4 SWOT Analysis
12.8.5 The SNS View
12.9 Xtant Medical Holdings Inc.
12.9.1 Company Overview
12.9.2 Financial
12.9.3 Products/ Services Offered
12.9.4 SWOT Analysis
12.9.5 The SNS View
12.10 Smith + Nephew
12.10.1 Company Overview
12.10.2 Financial
12.10.3 Products/ Services Offered
12.10.4 SWOT Analysis
12.10.5 The SNS View
12.11 Zimmer Biomet Holdings Inc.
12.11.1 Company Overview
12.11.2 Financial
12.11.3 Products/ Services Offered
12.11.4 SWOT Analysis
12.11.5 The SNS View
12.12 OST Laboratories
12.12.1 Company Overview
12.12.2 Financial
12.12.3 Products/ Services Offered
12.12.4 SWOT Analysis
12.12.5 The SNS View
13. Competitive Landscape
13.1 Competitive Benchmarking
13.2 Market Share Analysis
13.3 Recent Developments
13.3.1 Industry News
13.3.2 Company News
13.3.3 Mergers & Acquisitions
14. USE Cases And Best Practices
15. Conclusion
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