Bone Graft Market Report Scope & Overview:

The Bone Graft Market size was valued at US$ 4.46 Billion in 2022 and is projected to reach US$  6.69 Billion by 2030, with a growing CAGR of 5.2% over the forecast period 2023-2030.

Bone Graft is implantable material, which advances bone mending, bone arrangement, and bony remaking due to its osteoconductive, osteogenic, and osteoinductive properties. They are utilized in sports, injury, plastic, facial, and spinal medical procedures. What's more, they can be utilized to make up for shortfalls if there should be an occurrence of nonattendance of bones or help in the arrangement of underlying dependability. Bone graft is surgery for supplanting a missing or abandoned bone with a material (bone join) from a patient's own body, corpse, creature, or an alternate individual. It tracks down its application in injury mending, complex crack treatment, and others.

Bone Graft Market Revenue Analysis

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The development of the worldwide bone graft and substitutes market is driven by elements, for example, ascend in the occurrence of outer muscle problems, improvement of biocompatible engineered bone graft, mechanical headways in the clinical field prompting a shift from autograft to allograft, and expansion sought after for dental bone graft. In any case, greater expenses of medical procedures and moral issues connected with bone joining methodology are expected to restrict bone graft and substitute market development. On the other hand, expansion in the focal point of central participants toward R&D exercises in bone graft and their substitutes and upsurge sought after for muscular techniques among the geriatric populace is supposed to give worthwhile open doors to the market players later on.

Market Drivers

Extending pace of road wounds and joint issues

The pace of street wounds is on the ascent. For example, as per the WHO, around 20 to 50 million individuals experience non-lethal wounds, and roughly 1.35 million individuals kick the bucket because of street mishaps consistently. In addition, as per the National Trauma Institute, 2014, the financial weight because of injury cases has expanded to USD 671 billion, including medical care expenses and lost efficiency costs. Bone graft has various applications in fixing wounds and infections. It could be utilized on account of different or complex cracks or those that don't recuperate well after starting treatment. It is likewise utilized for a combination that assists two bones with recuperating in a sick joint. The Combination is most frequently done on the spine.

Improvement of biocompatible produced bone associations

Extended interest in dental bone associations

Market Restraints

The Significant expense of the medical procedures

  • The expense of a bone graft fluctuates generally relying upon the circumstance and the state of the patient. For instance, basic bone uniting for dental purposes utilizing engineered bone will cost anyplace from USD 300 to USD 800 for a solitary embed district. At the point when a patient's bone material is obtained from various pieces of the body for bone graft activity, hospitalization is required, which builds the expense. This type of graft additionally requires the administration of a muscular specialist and an anesthesiologist, bringing about a dental bone graft cost of USD 2,500 to USD 3,500.
  • Chance and entanglements from bone graft methods

Market Opportunities

High interest in the muscular consideration area

Thorough and practically identical appraisals of well-being spending in every nation are a critical contribution to well-being strategy and in proper order. They are important to help the accomplishments of public and global wellbeing objectives. On February 20, 2019, the WHO delivered another report on worldwide well-being consumption, as indicated by which the worldwide spending on well-being in low-and center pay nations expanded by 6%and in top-level salary nations by 4%. State-run administrations represent under 40%of essential medical services spending. Many organizations are grafting the area in light of the great market and an open door. Existing players are burning through huge amounts of cash on research and improvement to add cutting-edge innovations to their portfolios and keep up with their piece of the pie.

Value Chain Analysis

The bone graft substitute market is increasing and is supposed to keep developing consistently during the review time frame. This is because of the developing commitment of existing players to make the item more powerful. The store network investigation for the bone graft substitute market contains five significant parts, which begin with the examination and item advancement followed by assembling the items, dissemination, deals, and finishes with post-deals organizations.

The key market players center around integrating developments in their ongoing methods to keep any errors under control. For example, in July 2020, Baxter International Inc. declared the US Food and Drug Administration (FDA) freedom of Altapore Shape Bioactive Bone Graft to its cutting-edge bone graft substitute product offering.

COVID-19 Impact

The general effect of the COVID-19 pandemic is probably going to remain genuinely negative for clinical gadget organizations in the bone graft and substitute industry. Organizations are confronting a put-off, inferable from the lockdown, which has prompted interruptions in the store network exercises across the globe. Also, vital participants in the business are confronting issues as to the accessibility of human assets for assembling bone grafts and substitutes at creation offices. Also, end clients, for example, clinics and centers announced a decrease in quiet visits because of the lockdown limitations carried out around the world. In any case, this present circumstance is supposed to improve as the government has begun loosening up standards all over the planet for continuing business exercises. Besides, the interest in bone unions and substitutes is probably going to increment post-recommencing elective medical procedures and techniques soon.

Segment Overview

The bone graft substitute market has been partitioned in view of item type and application.

By Product Type


Allografts are the legitimate swap for autografts. Allografts are taken from people other than the one getting the join. For the most part, taken from corpses have given their bone so it very well may be utilized for individuals who are alive and out of luck; it is regularly obtained from a bone bank. However, there is a high gamble of sickness transmission while involving these allografts for bone joining as the body from which it is taken might be conveying the infection. Thus, these bones are profoundly handled and disinfected to lessen the possibility of sickness transmission. Allografts are portioned into machine allografts and Demineralized Bone Matrix (DB).

Bone Graft Substitute

The bone graft substitute is an engineered inorganic or naturally natural mix, which invigorates bone recuperating and fills bone deformities. It is additionally ordered into Bone Morphogenic Proteins (BMP) and engineered bone grafts.BMP are normally happening proteins found in the human body. These proteins animate the development of the bones normally in the human body. Various kinds of BMPs are found in the body. In any case, scientists have been zeroing in principally on the BMP-2 and BMP-7. These BMPs are significantly utilized in spinal combination treatment and are said to have an improved outcome than the other bone substitutes.

Cell-based Matrices

Progresses in the field of foundational microorganism innovation have animated the turn of events and expanded the utilization of allogeneic bone grafts containing live Mesenchymal Stem Cells (MSCs), otherwise called Cellular Bone Matrices (CBMs). Bone marrow and fat tissue are two of the primary wellsprings of these phones. It is assessed that CBMs include more than 17% of every bone graft and bone join substitute utilized.

By Application

The bone graft substitute market, by application, is sub-segmented into the dental, foot, and lower leg, joint recreation, long bone, and spinal combination. The spinal combination section overwhelmed the market in 2022. The spinal combination fragment is projected to be the quickest developing portion during the review time frame.

Spinal Fusion

The Spinal combination is a critical methodology wherein a strong scaffold is shaped between two vertebral spines to stop the development in that segment. It is vital to comprehend that bone grafts don't straightforwardly mend the spinal misery or do the spinal combination. In any case, bone graft establishes a climate for that strong extension to frame. Bone graft gives an establishment to the spine and permits the body to recover the bone and circuit the segment of the spine.

Joint Reconstruction

Joint recreation is a surgery used to fix and re-establish the full capacity of a given joint. It is one more muscular region where the utilization of bone join substitutes is unnecessarily finished. With the rising age, the human joints will generally become frail and are harmed in any event, during the littlest of mishaps or wounds. Also, there are sure situations, for example, sports injuries and vehicular mishaps, where the joints are removed or harmed.

Long Bone

Long bones are basically harmed because of extreme wounds, mishaps, injuries, or illnesses. They are intended to be solid and stable to adapt to the heaviness of the body. Engineered bone substitutes are not utilized for the remaking of long bones as they need development factors and other osteogenic properties. Autogenous unions or allografts are fundamentally utilized for long bone recreation.


Bone joining is essentially utilized in dental inserts to fix harmed or missing teeth. High level capacity and improved tasteful worth are a portion of the fundamental requirements for patients in this day and age. Bone grafts are utilized in dental reclamations as there is a prerequisite of enough bone volume and prevalent biologic properties for the right position of the dental inserts and the ideal results. Dental science has been progressively involving bone grafts alternative for supportive techniques.

Foot & Ankle
Bone grafting is a typical system for foot and lower leg-related medical procedures. Foot and lower leg medical procedures are critical as the patients having an ordinary existence are subject to whether they will actually want to walk in the future with no aggravation or imperfection. By and large, autografts were the favored decision, however because of drawbacks, for example, site dismalness, interest is ascending in utilizing bone join substitutes all things being equal. Engineered bone grafts, for example, calcium sulfate permit complex shapes to be etched and, surprisingly, percutaneous infusions to be performed. Calcium sulfate is a manufactured bone graft that permits complex shapes to be etched and even works with percutaneous infusions.

Key Market Segmentation:

By Product Type 

  • Allograft

  • Bone Graft Substitute

  • Cell-based Matrices

By Application

  • Spinal Fusion

  • Joint Reconstruction

  • Long Bone

  • Dental

  • Foot Ankle

  • Others

Bone Graft Market Segmentation Analysis

Regional Insights

North America overwhelmed the market with more than 40.0% portion of the worldwide income in 2021. Developing mindfulness connected with the economically available imaginative items, the openness of an advanced medical care structure, and higher medical services use of 16.9% in 2018 is the significant angles adding to the local market development. The market in the U.S. is driving the North American as well as worldwide market by creating the most extreme interest for bone grafts and substitutes on account of the developing number of injury-related wounds as well as instances of muscular infection.

Asia Pacific is assessed to observe rewarding development during the gauge time frame. This development can be ascribed to rising clinical the travel industry and ideal government drives. Then again, tough administrative rules limit the reception in a couple of countries. For example, in South Korea, the item must be supported prior to advertising by the Korean Food and Drug Administration (KFDA). In Australia, the items are directed by the Therapeutic Goods Administration (TGA). The tough administrative viewpoint in Japan confines the passage of unfamiliar players into the country. However, with the most recent endorsement of DBM in Japan in 2019, the allograft market is set to keep worthwhile development in the Asia Pacific over the course of the following 10 years.


North America

  • USA

  • Canada

  • Mexico


  • Germany

  • UK

  • France

  • Italy

  • Spain

  • The Netherlands

  • Rest of Europe


  • Japan

  • South Korea

  • China

  • India

  • Australia

  • Rest of Asia-Pacific

The Middle East & Africa

  • Israel

  • UAE

  • South Africa

  • Rest of Middle East & Africa

Latin America

  • Brazil

  • Argentina

  • Rest of Latin America

Key Players:

The major players are Arthrex Inc., Baxter International Inc., Integra Life Sciences Holdings Corporation, Johnson & Johnson (DePuy Synthes), Medtronic Plc., Musculoskeletal Transplant Foundation, NuVasive Inc., Stryker Corporation, Xtant Medical Holdings Inc., Zimmer Biomet Holdings Inc. and Other Players.

Johnson & Johnson (DePuy Synthes)-Company Financial Analysis

Company Landscape Analysis

Bone Graft Market Report Scope:
Report Attributes Details
Market Size in 2022  US$ 4.46 Billion
Market Size by 2030  US$ 6.69 Billion
CAGR  CAGR of 5.2% From 2023 to 2030
Base Year  2022
Forecast Period  2023-2030
Historical Data  2020-2021
Report Scope & Coverage Market Size, Segments Analysis, Competitive  Landscape, Regional Analysis, DROC & SWOT Analysis, Forecast Outlook
Key Segments • By Product Type (Allograft, Bone Graft Substitute, Cell-based Matrices)
• By Application (Spinal Fusion, Joint Reconstruction, Long Bone, Dental, Foot & Ankle, others)
Regional Analysis/Coverage North America (USA, Canada, Mexico), Europe
(Germany, UK, France, Italy, Spain, Netherlands,
Rest of Europe), Asia-Pacific (Japan, South Korea,
China, India, Australia, Rest of Asia-Pacific), The
Middle East & Africa (Israel, UAE, South Africa,
Rest of Middle East & Africa), Latin America (Brazil, Argentina, Rest of Latin America)
Company Profiles Arthrex Inc., Baxter International Inc., Integra Life Sciences Holdings Corporation, Johnson & Johnson (DePuy Synthes), Medtronic Plc., Musculoskeletal Transplant Foundation, NuVasive Inc., Stryker Corporation, Xtant Medical Holdings Inc., Zimmer Biomet Holdings Inc.
DRIVING FACTORS • Extending pace of road wounds and joint issues
Restraints • The expense of a bone graft fluctuates generally relying upon the circumstance and the state of the patient. For instance, basic bone uniting for dental purposes utilizing engineered bone will cost anyplace from USD 300 to USD 800 for a solitary embed district. At the point when a patient's bone material is obtained from various pieces of the body for a bone graft activity, hospitalization is required, which builds the expense. This type of graft additionally requires the administration of a muscular specialist and an anesthesiologist, bringing about a dental bone graft cost of USD 2,500 to USD 3,500.
• Chance and entanglements from bone graft methods

Frequently Asked Questions

Ans:- The bone graft Market was valued at USD 4.46 Bn by 2022.

Ans: The Bone Graft Market is growing at a CAGR of 5.2% over the forecast period 2023-2030.

North America was the greatest revenue contributor in the bone graft and alternatives market.

The forecast period for the bone graft market is 2022 to 2028.

. Key Stakeholders Considered in the study:

Raw material vendors


Regulatory authorities, including government agencies and NGO

Commercial research & development (R&D) institutions

Importers and exporters

Government organizations, research organizations, and consulting firms

Trade/Industrial associations

End-use industries are the stake holder of this report

Table of Contents

1. Introduction

1.1 Market Definition

1.2 Scope

1.3 Research Assumptions

2. Research Methodology

3. Market Dynamics

3.1 Drivers

3.2 Restraints

3.3 Opportunities

3.4 Challenges

4. Impact Analysis

4.1 COVID-19 Impact Analysis

4.2 Impact of Ukraine- Russia war

4.3 Impact of ongoing Recession

4.3.1 Introduction

4.3.2 Impact on major economies US Canada Germany France United Kingdom China Japan South Korea Rest of the World

5. Value Chain Analysis

6. Porter’s 5 forces model

7.  PEST Analysis

8. Bone Graft Market Segmentation, by product type

8.1 Allograft

8.2 Bone Graft Substitute

8.3 Cell-based Matrices

9. Bone Graft Market Segmentation, By application

9.1 Excavation and mining

9.2 Lifting and material handling

9.3 Earth moving

9.4 Transportation

9.5 Others 

10. Regional Analysis

10.1 Introduction

10.2 North America

10.2.1 USA

10.2.2     Canada

10.2.3     Mexico

10.3        Europe

10.3.1     Germany

10.3.2     UK

10.3.3     France

10.3.4     Italy

10.3.5     Spain

10.3.6     The Netherlands

10.3.7     Rest of Europe

10.4        Asia-Pacific

10.4.1     Japan

10.4.2     South Korea

10.4.3     China

10.4.4     India

10.4.5     Australia

10.4.6     Rest of Asia-Pacific

10.5        The Middle East & Africa

10.5.1     Israel

10.5.2     UAE

10.5.3     South Africa

10.5.4     Rest

10.6        Latin America

10.6.1     Brazil

10.6.2     Argentina

10.6.3     Rest of Latin America

11. Company Profiles


11.1.1 Financial

11.1.2 Products/ Services Offered

11.1.3 SWOT Analysis

11.1.4 The SNS view

11.2 Arthrex Inc.

11.3 Baxter International Inc.

11.4 Integra Life Sciences Holdings Corporation

11.5 Johnson & Johnson (DePuy Synthes)

11.6 Musculoskeletal Transplant Foundation

11.7 NuVasive Inc.

11.8 Stryker Corporation

11.9 Xtant Medical Holdings Inc.

11.10 Zimmer Biomet Holdings, Inc.

12. Competitive Landscape

12.1 Competitive Benchmark

12.2 Market Share Analysis

12.3 Recent Developments

13. Conclusion

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Secondary Research

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Primary Research

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Data Bank Validation

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