The DNA Synthesis Market size was estimated USD 2.9 billion in 2022 and is expected to reach USD 12.2 billion by 2030 at a CAGR of 19.7% during the forecast period of 2023-2030.
The natural formation of nucleic acid strands by DNA replication is known as DNA synthesis. They are created artificially in the laboratory utilizing genetic engineering and enzyme chemistry for a variety of purposes including therapeutics, diagnostics, and academic and industrial research. With the recent acceptance of DNA synthesis, several applications have grown in popularity.
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DRIVERS
Increasing usage in food and the agriculture industry
Increasing demand for DNA sequences and synthetic genes
The need for synthetic genes and DNA sequences has been fast expanding due to advances in synthetic biology and genetic engineering. Synthetic genes and DNA sequences can be utilized to make novel enzymes, proteins, and other compounds with unique features for use in a variety of applications. Furthermore, developments in DNA synthesis technology have made it easier and less expensive to create genes and DNA sequences. As a result, demand for synthetic genes and DNA sequences has increased, while the cost of DNA synthesis has decreased. These synthetic genes and DNA sequences have a wide range of uses, including gene therapy, medication development, and agricultural biotechnology. For example, Evonetix describes DNA synthesizer technology that will accelerate development across many therapeutic modalities.
RESTRAIN
Synthesis Errors and Quality Control
The process of DNA synthesis is not error-free, and errors may occur. Because of these flaws, DNA sequences that differ from the planned design are produced, resulting in inaccuracies in the final output. Maintaining high-quality control requirements and reducing synthesis errors are continuous challenges for DNA synthesis businesses. Accurate synthesis is required, especially for applications such as gene therapy or DNA-based diagnostics. DNA sequencing is used by manufacturers to ensure the accuracy of manufactured DNA sequences. This entails comparing the synthesized sequence to the intended design in order to find any differences. The amount of DNA produced is measured using several techniques such as UV spectroscopy or quantitative PCR (qPCR). This guarantees that the correct amount of DNA is produced.
OPPORTUNITY
Increasing demand for personalized medicine
DNA synthesis aids in the development of potentially life-saving medications. Personalized medicine is a drug that is tailored to a patient's individual therapeutic needs. It is based on data from pharmacogenomics, pharmacogenetics, pharmacometabolomics, and pharmacoproteomics. It aids in the early detection and prevention of many ailments, as well as the monitoring of therapy. Personalized medicine is also characterized as enhanced healthcare through the use of preventative medicine, rational medication development, therapeutic monitoring, and early illness identification. Scientists are developing individualized medication for patients with specific genetic variants and mutations by employing gene synthesis. The development of DNA-based diagnostic assays relies heavily on DNA synthesis. Synthetic DNA probes or primers are used in these assays to detect specific genetic sequences linked to diseases, infections, or genetic variants. The growing desire for personalized treatment and precise diagnostics has fueled the expansion of DNA-based diagnostics.
CHALLENGES
DNA synthesis can be an expensive operation, making it difficult for researchers on tight budgets to obtain the technology.
Possibility of unintentional release of synthetic DNA or the emergence of harmful diseases
In terms of the global pharmaceutical business, the war's influence has been limited to pharma manufacturers' investments and operations, as well as exporters' market interests in Russia, Ukraine, and other CIS nations, a phenomena that may be short-term and ephemeral. This is also because Russia and Ukraine are primarily pharma importing countries, implying that global pharma is not overly reliant on this region for essential raw materials and supplies. Indeed, some major pharmaceutical corporations have reduced their activities in Russia. However, there is merit to the notion that the pharmaceutical sector is dependent on oil and gas not just for transportation and logistics, but also because a huge number of pharmaceutical goods are derived from petrochemicals.
IMPACT OF ONGOING RECESSION
Many biopharmaceutical and biotechnology companies are now scrutinizing their spending and risk. Economic realities such as uncontrollable inflation, restricted capital, and supply chain challenges may hinder expansion goals, but there are reasons for optimism, as biotech experts recently emphasized. The research has shown that recessions can have an impact on medication demand for a variety of reasons, including lower use of patented biologics and branded pharmaceuticals, as well as an increase in utilization of biosimilars and generics.
By Service Type
Oligonucleotide Synthesis
Gene Synthesis
In 2022, Oligonucleotide Synthesis segment is expected to held the highest market share of 55.2% during the forecast period owing to oligonucleotide synthesis is a rapid and low-cost method of synthesizing desired oligonucleotide sequences. Furthermore, companies are embarking on strategic endeavors to introduce unique products, which will grow the segment. For example, in October 2022, Bachem announced a collaboration with Eli-Lilly and Company for the research and manufacturing of oligonucleotide-based APIs. The collaboration calls for Bachem to provide technical infrastructure and experience to help Lilly implement its new oligonucleotide manufacturing technique.
By Application
Research and Development
Diagnostics
Therapeutics
In 2022, the Research and Development segment is expected to dominate the market growth of 24.3% during the forecast period due to the technology, there are numerous benefits, such as speedy amplification, the requirement for a small amount of material, and utility in the detection of various diseases. When compared to other traditional methods, PCR allows for higher levels of amplification of specific sequences and more sensitive detection in less time, the technique is therefore particularly valuable for forensics, genetic identification testing, in vitro diagnostics, and industrial quality control. In clinical laboratories, real-time PCR has several advantages, including the simultaneous detection of several genes, lower reagent costs, the capacity to provide internal controls, and sample preservation for tumor profiling.
By End User
Biopharmaceutical Companies
Academic and Research Institutes
Contract Research Organizations
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In 2022, the Biopharmaceutical Companies segment is expected to dominate the market growth of 40.1% during the forecast period to due to increasing demand for biotechnology-based trade opportunities globally. Furthermore, synthetic nucleotides hasten the creation of enhanced bio-molecular therapeutics such as enzymes, peptides, RNA catalysts, and aptamers. Furthermore, because to advancements in nucleotide manufacturing processes and an emphasis on automation and autonomous technologies, businesses can now synthesis DNA fragments more quickly, inexpensively, and effectively. DNA synthesis is a fundamental molecular biology procedure that is important in a variety of domains, including genetic engineering and clinical diagnosis and treatment. Such elements are projected to dominate the segment.
North America held a significant market share of over 40.1% in 2022 due to the demand for synthetic nucleotides in this region is growing due to the various research projects in the region for emerging developments in biotechnology, including the rapid creation of medicines and vaccines, demand for synthetic nucleotides in this region is increasing.
Asia-Pacific is witness to expand fastest CAGR rate during the forecast period due to increased financing for biological research and drug development is increasing demand for a steady supply of synthetic nucleotides for use in research. Numerous ongoing research investigations at research institutions around the region, as well as emerging market participants, are positively impacting market growth.
REGIONAL COVERAGE
North America
US
Canada
Mexico
Europe
Eastern Europe
Poland
Romania
Hungary
Turkey
Rest of Eastern Europe
Western Europe
Germany
France
UK
Italy
Spain
Netherlands
Switzerland
Austria
Rest of Western Europe
Asia Pacific
China
India
Japan
South Korea
Vietnam
Singapore
Australia
Rest of Asia Pacific
Middle East & Africa
Middle East
UAE
Egypt
Saudi Arabia
Qatar
Rest of Middle East
Africa
Nigeria
South Africa
Rest of Africa
Latin America
Brazil
Argentina
Colombia
Rest of Latin America
The major key players are Thermo Fisher Scientific, Inc., Twist Bioscience, Bioneer Corporation, Eton Bioscience, LGC Biosearch Technologies, IBA GmbH, Eurofins Scientific, Integrated DNA Technologies, Inc., Quintara Biosciences, GenScript Biotech Corporation, and Others.
GenScript Biotech Corporation, in May 2023, GenScript Biotech Corporation created the GenTitan Gene Fragments Synthesis service to accelerate gene synthesis and reduce costs. This will allow the organization to broaden its service offerings and cater to a bigger consumer base.
Twist Bioscience, in January 2023, Twist Bioscience and Astellas have formed a research agreement to develop multitarget antibodies. The goal of this strategic alliance was to find antibodies against several targets of interest as well as curative medicines for individuals suffering from diseases with no therapeutic choices. This strategy is likely to assist the organization in improving its service offerings.
| Report Attributes | Details |
| Market Size in 2022 | US$ 2.9 Billion |
| Market Size by 2030 | US$ 12.2 Billion |
| CAGR | CAGR of 19.7% From 2023 to 2030 |
| Base Year | 2022 |
| Forecast Period | 2023-2030 |
| Historical Data | 2019-2021 |
| Report Scope & Coverage | Market Size, Segments Analysis, Competitive Landscape, Regional Analysis, DROC & SWOT Analysis, Forecast Outlook |
| Key Segments | • By Service Type (Oligonucleotide Synthesis, Gene Synthesis) • By Application (Research and Development, Diagnostics, Therapeutics) • By End User (Biopharmaceutical Companies, Academic and Research Institutes, Contract Research Organizations) |
| Regional Analysis/Coverage | North America (US, Canada, Mexico), Europe (Eastern Europe [Poland, Romania, Hungary, Turkey, Rest of Eastern Europe] Western Europe] Germany, France, UK, Italy, Spain, Netherlands, Switzerland, Austria, Rest of Western Europe]), Asia Pacific (China, India, Japan, South Korea, Vietnam, Singapore, Australia, Rest of Asia Pacific), Middle East & Africa (Middle East [UAE, Egypt, Saudi Arabia, Qatar, Rest of Middle East], Africa [Nigeria, South Africa, Rest of Africa], Latin America (Brazil, Argentina, Colombia Rest of Latin America) |
| Company Profiles | Thermo Fisher Scientific, Inc., Twist Bioscience, Bioneer Corporation, Eton Bioscience, LGC Biosearch Technologies, IBA GmbH, Eurofins Scientific, Integrated DNA Technologies, Inc., Quintara Biosciences, GenScript Biotech Corporation |
| Key Drivers | • Increasing usage in food and the agriculture industry • Increasing demand for DNA sequences and synthetic genes |
| Market Challenges | • DNA synthesis can be an expensive operation, making it difficult for researchers on tight budgets to obtain the technology. • Possibility of unintentional release of synthetic DNA or the emergence of harmful diseases |
Ans: Analytical Instrumentation Market size was valued at USD 2.9 billion in 2022.
Ans: DNA Synthesis Market is anticipated to expand by 19.7% from 2023 to 2030.
Ans: North America held a significant market share of around 45.8% in 2022.
Ans: USD 12.2 billion is expected to grow by 2030.
Ans: Risk of accidental release of synthetic DNA or the creation of dangerous pathogens.
Table of Contents
1. Introduction
1.1 Market Definition
1.2 Scope
1.3 Research Assumptions
2. Research Methodology
3. Market Dynamics
3.1 Drivers
3.2 Restraints
3.3 Opportunities
3.4 Challenges
4. Impact Analysis
4.1 Impact of the Ukraine- Russia war
4.2 Impact of ongoing Recession
4.2.1 Introduction
4.2.2 Impact on major economies
4.2.2.1 US
4.2.2.2 Canada
4.2.2.3 Germany
4.2.2.4 France
4.2.2.5 United Kingdom
4.2.2.6 China
4.2.2.7 Japan
4.2.2.8 South Korea
4.2.2.9 Rest of the World
5. Value Chain Analysis
6. Porter’s 5 forces model
7. PEST Analysis
8. DNA Synthesis Market Segmentation, By Service Type
8.1 Oligonucleotide Synthesis
8.2 Gene Synthesis
9. DNA Synthesis Market Segmentation, By Application
9.1 Research and Development
9.2 Diagnostics
9.3 Therapeutics
10. DNA Synthesis Market Segmentation, By End User
10.1 Biopharmaceutical Companies
10.2 Academic and Research Institutes
10.3 Contract Research Organizations
11. Regional Analysis
11.1 Introduction
11.2 North America
11.2.1 North America DNA Synthesis Market by Country
11.2.2 North America DNA Synthesis Market by Service Type
11.2.3 North America DNA Synthesis Market by Application
11.2.4 North America DNA Synthesis Market by End User
11.2.5 USA
11.2.5.1 USA DNA Synthesis Market by Service Type
11.2.5.2 USA DNA Synthesis Market by Application
11.2.5.3 USA DNA Synthesis Market by End User
11.2.6 Canada
11.2.6.1 Canada DNA Synthesis Market by Service Type
11.2.6.2 Canada DNA Synthesis Market by Application
11.2.6.3 Canada DNA Synthesis Market by End User
11.2.7 Mexico
11.2.7.1 Mexico DNA Synthesis Market by Service Type
11.2.7.2 Mexico DNA Synthesis Market by Application
11.2.7.3 Mexico DNA Synthesis Market by End User
11.3 Europe
11.3.1 Eastern Europe
11.3.1.1 Eastern Europe DNA Synthesis Market by Country
11.3.1.2 Eastern Europe DNA Synthesis Market by Service Type
11.3.1.3 Eastern Europe DNA Synthesis Market by Application
11.3.1.4 Eastern Europe DNA Synthesis Market by End User
11.3.1.5 Poland
11.3.1.5.1 Poland DNA Synthesis Market by Service Type
11.3.1.5.2 Poland DNA Synthesis Market by Application
11.3.1.5.3 Poland DNA Synthesis Market by End User
11.3.1.6 Romania
11.3.1.6.1 Romania DNA Synthesis Market by Service Type
11.3.1.6.2 Romania DNA Synthesis Market by Application
11.3.1.6.4 Romania DNA Synthesis Market by End User
11.3.1.7 Turkey
11.3.1.7.1 Turkey DNA Synthesis Market by Service Type
11.3.1.7.2 Turkey DNA Synthesis Market by Application
11.3.1.7.3 Turkey DNA Synthesis Market by End User
11.3.1.8 Rest of Eastern Europe
11.3.1.8.1 Rest of Eastern Europe DNA Synthesis Market by Service Type
11.3.1.8.2 Rest of Eastern Europe DNA Synthesis Market by Application
11.3.1.8.3 Rest of Eastern Europe DNA Synthesis Market by End User
11.3.2 Western Europe
11.3.2.1 Western Europe DNA Synthesis Market by Service Type
11.3.2.2 Western Europe DNA Synthesis Market by Application
11.3.2.3 Western Europe DNA Synthesis Market by End User
11.3.2.4 Germany
11.3.2.4.1 Germany DNA Synthesis Market by Service Type
11.3.2.4.2 Germany DNA Synthesis Market by Application
11.3.2.4.3 Germany DNA Synthesis Market by End User
11.3.2.5 France
11.3.2.5.1 France DNA Synthesis Market by Service Type
11.3.2.5.2 France DNA Synthesis Market by Application
11.3.2.5.3 France DNA Synthesis Market by End User
11.3.2.6 UK
11.3.2.6.1 UK DNA Synthesis Market by Service Type
11.3.2.6.2 UK DNA Synthesis Market by Application
11.3.2.6.3 UK DNA Synthesis Market by End User
11.3.2.7 Italy
11.3.2.7.1 Italy DNA Synthesis Market by Service Type
11.3.2.7.2 Italy DNA Synthesis Market by Application
11.3.2.7.3 Italy DNA Synthesis Market by End User
11.3.2.8 Spain
11.3.2.8.1 Spain DNA Synthesis Market by Service Type
11.3.2.8.2 Spain DNA Synthesis Market by Application
11.3.2.8.3 Spain DNA Synthesis Market by End User
11.3.2.9 Netherlands
11.3.2.9.1 Netherlands DNA Synthesis Market by Service Type
11.3.2.9.2 Netherlands DNA Synthesis Market by Application
11.3.2.9.3 Netherlands DNA Synthesis Market by End User
11.3.2.10 Switzerland
11.3.2.10.1 Switzerland DNA Synthesis Market by Service Type
11.3.2.10.2 Switzerland DNA Synthesis Market by Application
11.3.2.10.3 Switzerland DNA Synthesis Market by End User
11.3.2.11.1 Austria
11.3.2.11.2 Austria DNA Synthesis Market by Service Type
11.3.2.11.3 Austria DNA Synthesis Market by Application
11.3.2.11.4 Austria DNA Synthesis Market by End User
11.3.2.12 Rest of Western Europe
11.3.2.12.1 Rest of Western Europe DNA Synthesis Market by Service Type
11.3.2.12.2 Rest of Western Europe DNA Synthesis Market by Application
11.3.2.12.3 Rest of Western Europe DNA Synthesis Market by End User
11.4 Asia-Pacific
11.4.1 Asia-Pacific DNA Synthesis Market by Country
11.4.2 Asia-Pacific DNA Synthesis Market by Service Type
11.4.3 Asia-Pacific DNA Synthesis Market by Application
11.4.4 Asia-Pacific DNA Synthesis Market by End User
11.4.5 China
11.4.5.1 China DNA Synthesis Market by Service Type
11.4.5.2 China DNA Synthesis Market by End User
11.4.5.3 China DNA Synthesis Market by Application
11.4.6 India
11.4.6.1 India DNA Synthesis Market by Service Type
11.4.6.2 India DNA Synthesis Market by Application
11.4.6.3 India DNA Synthesis Market by End User
11.4.7 Japan
11.4.7.1 Japan DNA Synthesis Market by Service Type
11.4.7.2 Japan DNA Synthesis Market by Application
11.4.7.3 Japan DNA Synthesis Market by End User
11.4.8 South Korea
11.4.8.1 South Korea DNA Synthesis Market by Service Type
11.4.8.2 South Korea DNA Synthesis Market by Application
11.4.8.3 South Korea DNA Synthesis Market by End User
11.4.9 Vietnam
11.4.9.1 Vietnam DNA Synthesis Market by Service Type
11.4.9.2 Vietnam DNA Synthesis Market by Application
11.4.9.3 Vietnam DNA Synthesis Market by End User
11.4.10 Singapore
11.4.10.1 Singapore DNA Synthesis Market by Service Type
11.4.10.2 Singapore DNA Synthesis Market by Application
11.4.10.3 Singapore DNA Synthesis Market by End User
11.4.11 Australia
11.4.11.1 Australia DNA Synthesis Market by Service Type
11.4.11.2 Australia DNA Synthesis Market by Application
11.4.11.3 Australia DNA Synthesis Market by End User
11.4.12 Rest of Asia-Pacific
11.4.12.1 Rest of Asia-Pacific DNA Synthesis Market by Service Type
11.4.12.2 Rest of Asia-Pacific DNA Synthesis Market by Application
11.4.12.3 Rest of Asia-Pacific DNA Synthesis Market by End User
11.5 Middle East & Africa
11.5.1 Middle East
11.5.1.1 Middle East DNA Synthesis Market by Country
11.5.1.2 Middle East DNA Synthesis Market by Service Type
11.5.1.3 Middle East DNA Synthesis Market by Application
11.5.1.4 Middle East DNA Synthesis Market by End User
11.5.1.5 UAE
11.5.1.5.1 UAE DNA Synthesis Market by Service Type
11.5.1.5.2 UAE DNA Synthesis Market by Application
11.5.1.5.3 UAE DNA Synthesis Market by End User
11.5.1.6 Egypt
11.5.1.6.1 Egypt DNA Synthesis Market by Service Type
11.5.1.6.2 Egypt DNA Synthesis Market by Application
11.5.1.6.3 Egypt DNA Synthesis Market by End User
11.5.1.7 Saudi Arabia
11.5.1.7.1 Saudi Arabia DNA Synthesis Market by Service Type
11.5.1.7.2 Saudi Arabia DNA Synthesis Market by Application
11.5.1.7.3 Saudi Arabia DNA Synthesis Market by End User
11.5.1.8 Qatar
11.5.1.8.1 Qatar DNA Synthesis Market by Service Type
11.5.1.8.2 Qatar DNA Synthesis Market by Application
11.5.1.8.3 Qatar DNA Synthesis Market by End User
11.5.1.9 Rest of Middle East
11.5.1.9.1 Rest of Middle East DNA Synthesis Market by Service Type
11.5.1.9.2 Rest of Middle East DNA Synthesis Market by Application
11.5.1.9.3 Rest of Middle East DNA Synthesis Market by End User
11.5.2 Africa
11.5.2.1 Africa Transfusion Diagnostics Market by Country
11.5.2.2 Africa DNA Synthesis Market by Service Type
11.5.2.3 Africa DNA Synthesis Market by Application
11.5.2.4 Africa DNA Synthesis Market by End User
11.5.2.5 Nigeria
11.5.2.5.1 Nigeria DNA Synthesis Market by Service Type
11.5.2.5.2 Nigeria DNA Synthesis Market by Application
11.5.2.5.3 Nigeria DNA Synthesis Market by End User
11.5.2.6 South Africa
11.5.2.6.1 South Africa DNA Synthesis Market by Service Type
11.5.2.6.2 South Africa DNA Synthesis Market by Application
11.5.2.6.3 South Africa DNA Synthesis Market by End User
11.5.2.7 Rest of Africa
11.5.2.7.1 Rest of Africa DNA Synthesis Market by Service Type
11.5.2.7.2 Rest of Africa DNA Synthesis Market by Application
11.5.2.7.3 Rest of Africa DNA Synthesis Market by End User
11.6 Latin America
11.6.1 Latin America DNA Synthesis Market by Country
11.6.2 Latin America DNA Synthesis Market by Service Type
11.6.3 Latin America DNA Synthesis Market by Application
11.6.4 Latin America DNA Synthesis Market by End User
11.6.5 Brazil
11.6.5.1 Brazil DNA Synthesis Market by Service Type
11.6.5.2 Brazil DNA Synthesis Market by Application
11.6.5.3 Brazil DNA Synthesis Market by End User
11.6.6 Argentina
11.6.6.1 Argentina DNA Synthesis Market by Service Type
11.6.6.2 Argentina DNA Synthesis Market by Application
11.6.6.3 Argentina DNA Synthesis Market by End User
11.6.7 Colombia
11.6.7.1 Colombia DNA Synthesis Market by Service Type
11.6.7.2 Colombia DNA Synthesis Market by Application
11.6.7.3 Colombia DNA Synthesis Market by End User
11.6.8 Rest of Latin America
11.6.8.1 Rest of Latin America DNA Synthesis Market by Service Type
11.6.8.2 Rest of Latin America DNA Synthesis Market by Application
11.6.8.3 Rest of Latin America DNA Synthesis Market by End User
12. Company profile
12.1 Thermo Fisher Scientific, Inc.
12.1.1 Company Overview
12.1.2 Financial
12.1.3 Service Types/ Services Offered
12.1.4 SWOT Analysis
12.1.5 The SNS View
12.2 Twist Bioscience
12.2.1 Company Overview
12.2.2 Financials
12.2.3 Service Type/Services Offered
12.2.4 SWOT Analysis
12.2.5 The SNS View
12.3 Bioneer Corporation
12.3.1 Company Overview
12.3.2 Financials
12.3.3 Service Type/Services Offered
12.3.4 SWOT Analysis
12.3.5 The SNS View
12.4 Eton Bioscience
12.4.1 Company Overview
12.4.2 Financials
12.4.3 Service Type/Services Offered
12.4.4 SWOT Analysis
12.4.5 The SNS View
12.5 LGC Biosearch Technologies
12.5.1 Company Overview
12.5.2 Financials
12.5.3 Service Type/Services Offered
12.5.4 SWOT Analysis
12.5.5 The SNS View
12.6 IBA GmbH
12.6.1 Company Overview
12.6.2 Financials
12.6.3 Service Type/Services Offered
12.6.4 SWOT Analysis
12.6.5 The SNS View
12.7 Eurofins Scientific
12.7.1 Company Overview
12.7.2 Financials
12.7.3 Service Type/Services Offered
12.7.4 SWOT Analysis
12.7.5 The SNS View
12.8 Integrated DNA Technologies, Inc.
12.8.1 Company Overview
12.8.2 Financials
12.8.3 Service Type/Services Offered
12.8.4 SWOT Analysis
12.8.5 The SNS View
12.9 Quintara Biosciences
12.9.1 Company Overview
12.9.2 Financials
12.9.3 Service Type/Services Offered
12.9.4 SWOT Analysis
12.9.5 The SNS View
12.10 GenScript Biotech Corporation
12.10.1 Company Overview
12.10.2 Financials
12.10.3 Service Type/Services Offered
12.10.4 SWOT Analysis
12.10.5 The SNS View
12.11 Others
13. Competitive Landscape
13.1 Competitive Bench marking
13.2 Market Share Analysis
13.3 Recent Developments
13.3.1 Industry News
13.3.2 Company News
13.3.3 Mergers & Acquisitions
14. Use Case and Best Practices
15. Conclusion
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