The Downstream Processing Market Size was valued at USD 28.24 billion in 2022, and is expected to reach USD 80.01 billion by 2030 and grow at a CAGR of 13.9% over the forecast period 2023-2030.
The term "downstream processing" refers to the recovery and purification of biosynthetic goods, primarily pharmaceuticals, from natural sources like plant tissues, fermentation broth, and animal tissues. It also includes the recycling of parts that can be reused, as well as the proper handling and disposal of waste. Pharmaceuticals including hormones, antibodies, vaccines, and antibiotics, as well as industrial enzymes, flavorings, and natural scent compounds, are produced during this crucial period.
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DRIVERS
An expanding market for biopharmaceuticals
A Rise in R&D Spending by Biopharmaceutical Companies
RESTRAINTS
Instruments are very expensive.
Limited availability of experts
Regulators are paying more attention to the cleaning certification of downstream purification processes
OPPORTUNITIES
Improvements in downstream processing
Rising need for monoclonal antibodies
CHALLENGES
The bottleneck in the purification process
Insufficient single-use options
Over the forecast period, it is expected that COVID-19's increased prevalence would have a positive impact on market growth. The bulk of pharmaceutical and biopharmaceutical companies suffered large losses as the coronavirus outbreak persisted, which hurt the downstream processing sector. In the early stages of the epidemic, several businesses curtailed or stopped their production and supply activities. The downstream processing market has also been negatively impacted by the lack of raw material supplies. In response to the COVID-19 pandemic, social distancing policies were implemented, and resources were redistributed, which significantly disrupted the worldwide pharmaceutical and biopharmaceutical businesses.
The need for downstream processing goods has, however, unexpectedly increased as a result of the rising demand for the COVID-19 vaccine. To meet the demand for the products, the major players in the downstream processing sector have boosted production.
By Technique
Solid-liquid separation, Clarification/concentration, and purification are the market segments. The market's largest share was accounted for by the purification category. This rapid expansion is attributable to the requirement for extremely pure biopharmaceutical goods to satisfy regulatory requirements, as downstream purification significantly contributes to improving the purity and quality of products, which supports the expansion of the purification industry.
By Product
The market is divided into chromatography columns and membrane adsorbers, resins, filters, single-use items, and miscellaneous products. The market's greatest share belonged to the category for chromatography columns and resins. The ongoing demand for newer and varied types of columns and resins is anticipated to drive market expansion.
By Application
The downstream processing market is divided into the manufacturing of monoclonal antibodies (mAbs), vaccines, insulin, immunoglobulins, erythropoietin, and other applications. The market's largest share belonged to the production of vaccines. The development of high-quality products like vaccines at cheaper costs through technological innovation in downstream purification is anticipated to fuel the growth of this market.
By End User
Biopharmaceutical producers and contract manufacturing businesses make up the market segments. The market's highest share belonged to the group of biopharmaceutical producers. The end-user market for biopharmaceutical producers is predicted to increase more quickly because to the ageing population's rising demand for these products.
By Technique
Purification
Solid-liquid Separation
Clarification/Concentration
By Product
Chromatography Columns and Resins
Filters
Membrane Adsorbers
Single-use Products
By Application
Monoclonal Antibody Production
Vaccine Production
Insulin Production
Immunoglobulin Production
Erythropoietin Production
By End User
Biopharmaceutical Manufacturers
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Because of its developed healthcare system, high level of government support for fostering bioprocess technology, and rise in medical spending, North America has the largest downstream processing market share and is anticipated to dominate during the projection period. However, due to increased biotechnology investment and the presence of a sizable patient base, which hastens the need for cutting-edge medical technologies to create biopharmaceuticals for the treatment of various diseases, Asia-Pacific is predicted to experience the highest CAGR during the forecasted period.
REGIONAL COVERAGE
North America
USA
Canada
Mexico
Europe
Germany
UK
France
Italy
Spain
The Netherlands
Rest of Europe
Asia-Pacific
Japan
south Korea
China
India
Australia
Rest of Asia-Pacific
The Middle East & Africa
Israel
UAE
South Africa
Rest of Middle East & Africa
Latin America
Brazil
Argentina
Rest of Latin America
Some of the major key players are Asahi Kasei Corporation, Boehringer Ingelheim, Corning Incorporated, Danaher Corporation, Eppendorf AG, 3M Company, Merck Millipore, Lonza Group AG, Sartorius Stedim Biotech S.A., Thermo Fisher Scientific Inc. and Other Players.
| Report Attributes | Details |
|---|---|
| Market Size in 2022 | US$ 28.24 Billion |
| Market Size by 2030 | US$ 80.01 Billion |
| CAGR | CAGR of 13.9% From 2023 to 2030 |
| Base Year | 2022 |
| Forecast Period | 2023-2030 |
| Historical Data | 2020-2021 |
| Report Scope & Coverage | Market Size, Segments Analysis, Competitive Landscape, Regional Analysis, DROC & SWOT Analysis, Forecast Outlook |
| Key Segments | • By Technique (Purification, Solid-liquid Separation, Clarification/Concentration) • By Product (Chromatography Columns and Resins, Filters, Membrane Adsorbers, Single-use Products) • By Application (Monoclonal Antibody Production, Vaccine Production, Insulin Production, Immunoglobulin Production, Erythropoietin Production) • By End User (Biopharmaceutical Manufacturers, Contract Manufacturing Organizations (CMOs)) |
| Regional Analysis/Coverage | North America (USA, Canada, Mexico), Europe (Germany, UK, France, Italy, Spain, Netherlands, Rest of Europe), Asia-Pacific (Japan, South Korea, China, India, Australia, Rest of Asia-Pacific), The Middle East & Africa (Israel, UAE, South Africa, Rest of Middle East & Africa), Latin America (Brazil, Argentina, Rest of Latin America) |
| Company Profiles | Asahi Kasei Corporation, Boehringer Ingelheim, Corning Incorporated, Danaher Corporation, Eppendorf AG, 3M Company, Merck Millipore, Lonza Group AG, Sartorius Stedim Biotech S.A., Thermo Fisher Scientific Inc. |
| Key Drivers | • An expanding market for biopharmaceuticals • A Rise in R&D Spending by Biopharmaceutical Companies |
| RESTRAINTS | • Instruments are very expensive. • Limited availability of experts. |
Ans. The Downstream Processing Market Size was valued at USD 28.24 billion in 2022.
Ans. The Downstream Processing Market is growing at a CAGR of 13.9% over the forecast period 2023-2030.
Ans. Key drivers of the Downstream Processing Market is an expanding market for biopharmaceuticals, and A Rise in R&D Spending by Biopharmaceutical Companies
Ans. Asahi Kasei Corporation, Boehringer Ingelheim, Corning Incorporated, Danaher Corporation, Eppendorf AG are the key plyer of Downstream Processing Market
Ans. Top-down, bottom-up, Quantitative, Qualitative Research, Descriptive, Analytical, Applied, Fundamental Research.
Table of Contents
1. Introduction
1.1 Market Definition
1.2 Scope
1.3 Research Assumptions
2. Research Methodology
3. Market Dynamics
3.1 Drivers
3.2 Restraints
3.3 Opportunities
3.4 Challenges
4. Impact Analysis
4.1 COVID-19 Impact Analysis
4.2 Impact of Ukraine- Russia War
4.3 Impact of Ongoing Recession
4.3.1 Introduction
4.3.2 Impact on major economies
4.3.2.1 US
4.3.2.2 Canada
4.3.2.3 Germany
4.3.2.4 France
4.3.2.5 United Kingdom
4.3.2.6 China
4.3.2.7 Japan
4.3.2.8 South Korea
4.3.2.9 Rest of the World
5. Value Chain Analysis
6. Porter’s 5 forces model
7. PEST Analysis
8. Downstream Processing Market Segmentation, By Technique
8.1 Purification
8.2 Solid-liquid Separation
8.3 Clarification/Concentration
9. Downstream Processing Market Segmentation, By Product
9.1 Chromatography Columns and Resins
9.2 Filters
9.3 Membrane Adsorbers
9.4 Single-use Products
10. Downstream Processing Market Segmentation, By Application
10.1 Monoclonal Antibody Production
10.2 Vaccine Production
10.3 Insulin Production
10.4 Immunoglobulin Production
10.5 Erythropoietin Production
11. Downstream Processing Market Segmentation, By End User
11.1 Biopharmaceutical Manufacturers
11.2 Contract Manufacturing Organizations (CMOs)
12. Regional Analysis
12.1 Introduction
12.2 North America
12.2.1 USA
12.2.2 Canada
12.2.3 Mexico
12.3 Europe
12.3.1 Germany
12.3.2 UK
12.3.3 France
12.3.4 Italy
12.3.5 Spain
12.3.6 The Netherlands
12.3.7 Rest of Europe
12.4 Asia-Pacific
12.4.1 Japan
12.4.2 South Korea
12.4.3 China
12.4.4 India
12.4.5 Australia
12.4.6 Rest of Asia-Pacific
12.5 The Middle East & Africa
12.5.1 Israel
12.5.2 UAE
12.5.3 South Africa
12.5.4 Rest
12.6 Latin America
12.6.1 Brazil
12.6.2 Argentina
12.6.3 Rest of Latin America
13. Company Profiles
13.1 Asahi Kasei Corporation
13.1.1 Financial
13.1.2 Products/ Services Offered
13.1.3 SWOT Analysis
13.1.4 The SNS view
13.2 Boehringer Ingelheim
13.3 Corning Incorporated
13.4 Danaher Corporation
13.5 Eppendorf AG
13.6 3M Company
13.7 Merck Millipore
13.8 Lonza Group AG
13.9 Sartorius Stedim Biotech S.A.
13.10 Thermo Fisher Scientific Inc.
14. Competitive Landscape
14.1 Competitive Benchmark
14.2 Market Share Analysis
14.3 Recent Developments
15. Conclusion
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