Downstream Processing Market Report Scope & Overview:

The Downstream Processing Market Size was valued at USD 35.89 billion in 2023, and is expected to reach USD 109.78 billion by 2031 and grow at a CAGR of 15% over the forecast period 2024-2031.

The term "downstream processing" refers to the recovery and purification of biosynthetic goods, primarily pharmaceuticals, from natural sources like plant tissues, fermentation broth, and animal tissues. It also includes the recycling of parts that can be reused, as well as the proper handling and disposal of waste. Pharmaceuticals including hormones, antibodies, vaccines, and antibiotics, as well as industrial enzymes, flavorings, and natural scent compounds, are produced during this crucial period.

Downstream Processing Market Revenue Analysis

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  • An expanding market for biopharmaceuticals

  • A Rise in R&D Spending by Biopharmaceutical Companies


  • Instruments are very expensive.

  • Limited availability of experts

  • Regulators are paying more attention to the cleaning certification of downstream purification processes


  • Improvements in downstream processing

  • Rising need for monoclonal antibodies


  • The bottleneck in the purification process

  • Insufficient single-use options


Over the forecast period, it is expected that COVID-19's increased prevalence would have a positive impact on market growth. The bulk of pharmaceutical and biopharmaceutical companies suffered large losses as the coronavirus outbreak persisted, which hurt the downstream processing sector. In the early stages of the epidemic, several businesses curtailed or stopped their production and supply activities. The downstream processing market has also been negatively impacted by the lack of raw material supplies. In response to the COVID-19 pandemic, social distancing policies were implemented, and resources were redistributed, which significantly disrupted the worldwide pharmaceutical and biopharmaceutical businesses.

The need for downstream processing goods has, however, unexpectedly increased as a result of the rising demand for the COVID-19 vaccine. To meet the demand for the products, the major players in the downstream processing sector have boosted production.

By Technique

Solid-liquid separation, Clarification/concentration, and purification are the market segments. The market's largest share was accounted for by the purification category. This rapid expansion is attributable to the requirement for extremely pure biopharmaceutical goods to satisfy regulatory requirements, as downstream purification significantly contributes to improving the purity and quality of products, which supports the expansion of the purification industry.

By Product

The market is divided into chromatography columns and membrane adsorbers, resins, filters, single-use items, and miscellaneous products. The market's greatest share belonged to the category for chromatography columns and resins. The ongoing demand for newer and varied types of columns and resins is anticipated to drive market expansion.

By Application

The downstream processing market is divided into the manufacturing of monoclonal antibodies (mAbs), vaccines, insulin, immunoglobulins, erythropoietin, and other applications. The market's largest share belonged to the production of vaccines. The development of high-quality products like vaccines at cheaper costs through technological innovation in downstream purification is anticipated to fuel the growth of this market.

By End User

Biopharmaceutical producers and contract manufacturing businesses make up the market segments. The market's highest share belonged to the group of biopharmaceutical producers. The end-user market for biopharmaceutical producers is predicted to increase more quickly because to the ageing population's rising demand for these products.


By Technique

  • Purification

  • Solid-liquid Separation

  • Clarification/Concentration

By Product

  • Chromatography Columns and Resins

  • Filters

  • Membrane Adsorbers

  • Single-use Products

By Application

  • Monoclonal Antibody Production

  • Vaccine Production

  • Insulin Production

  • Immunoglobulin Production

  • Erythropoietin Production

By End User


Because of its developed healthcare system, high level of government support for fostering bioprocess technology, and rise in medical spending, North America has the largest downstream processing market share and is anticipated to dominate during the projection period. However, due to increased biotechnology investment and the presence of a sizable patient base, which hastens the need for cutting-edge medical technologies to create biopharmaceuticals for the treatment of various diseases, Asia-Pacific is predicted to experience the highest CAGR during the forecasted period.

Downstream Processing Market By Region

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  • North America

    • USA

    • Canada

    • Mexico

  • Europe

    • Germany

    • UK

    • France

    • Italy

    • Spain

    • The Netherlands

    • Rest of Europe

  • Asia-Pacific

    • Japan

    • south Korea

    • China

    • India

    • Australia

    • Rest of Asia-Pacific

  • The Middle East & Africa

    • Israel

    • UAE

    • South Africa

    • Rest of Middle East & Africa

  • Latin America

    • Brazil

    • Argentina

    • Rest of Latin America


Some of the major key players are Asahi Kasei Corporation, Boehringer Ingelheim, Corning Incorporated, Danaher Corporation, Eppendorf AG, 3M Company, Merck Millipore, Lonza Group AG, Sartorius Stedim Biotech S.A., Thermo Fisher Scientific Inc. and Other Players.

Corning Incorporated-Company Financial Analysis

Company Landscape Analysis

Downstream Processing Market Report Scope:

Report Attributes Details
Market Size in 2023 US$ 35.89 Billion
Market Size by 2031 US$ 109.78  Billion
CAGR CAGR of 15% From 2024 to 2031
Base Year 2023
Forecast Period 2024-2031
Historical Data 2020-2022
Report Scope & Coverage Market Size, Segments Analysis, Competitive  Landscape, Regional Analysis, DROC & SWOT Analysis, Forecast Outlook
Key Segments • By Technique (Purification, Solid-liquid Separation, Clarification/Concentration)
• By Product (Chromatography Columns and Resins, Filters, Membrane Adsorbers, Single-use Products)
• By Application (Monoclonal Antibody Production, Vaccine Production, Insulin Production, Immunoglobulin Production, Erythropoietin Production)
• By End User (Biopharmaceutical Manufacturers, Contract Manufacturing Organizations (CMOs))
Regional Analysis/Coverage North America (USA, Canada, Mexico), Europe
(Germany, UK, France, Italy, Spain, Netherlands,
Rest of Europe), Asia-Pacific (Japan, South Korea,
China, India, Australia, Rest of Asia-Pacific), The
Middle East & Africa (Israel, UAE, South Africa,
Rest of Middle East & Africa), Latin America (Brazil, Argentina, Rest of Latin America)
Company Profiles Asahi Kasei Corporation, Boehringer Ingelheim, Corning Incorporated, Danaher Corporation, Eppendorf AG, 3M Company, Merck Millipore, Lonza Group AG, Sartorius Stedim Biotech S.A., Thermo Fisher Scientific Inc.
Key Drivers • An expanding market for biopharmaceuticals
• A Rise in R&D Spending by Biopharmaceutical Companies
RESTRAINTS • Instruments are very expensive.
• Limited availability of experts.

Frequently Asked Questions

Ans. The Downstream Processing Market Size was valued at USD 35.89 billion in 2023.

Ans. The Downstream Processing Market is growing at a CAGR of 15% over the forecast period 2024-2031.

Ans. Key drivers of the Downstream Processing Market is an expanding market for biopharmaceuticals, and A Rise in R&D Spending by Biopharmaceutical Companies 

Ans. Asahi Kasei Corporation, Boehringer Ingelheim, Corning Incorporated, Danaher Corporation, Eppendorf AG are the key plyer of Downstream Processing Market

Ans.  Top-down, bottom-up, Quantitative, Qualitative Research, Descriptive, Analytical, Applied, Fundamental Research.

Table of Contents

1. Introduction

1.1 Market Definition

1.2 Scope

1.3 Research Assumptions

2. Research Methodology

3. Market Dynamics

3.1 Drivers

3.2 Restraints

3.3 Opportunities

3.4 Challenges

4. Impact Analysis

4.1 COVID-19 Impact Analysis

4.2 Impact of Ukraine- Russia War

4.3 Impact of Ongoing Recession

4.3.1 Introduction

4.3.2 Impact on major economies US Canada Germany France United Kingdom China Japan South Korea Rest of the World

5. Value Chain Analysis

6. Porter’s 5 forces model

7.  PEST Analysis

8. Downstream Processing Market Segmentation, By Technique

8.1 Purification

8.2 Solid-liquid Separation

8.3 Clarification/Concentration

9. Downstream Processing Market Segmentation, By Product

9.1 Chromatography Columns and Resins

9.2 Filters

9.3 Membrane Adsorbers

9.4 Single-use Products

10. Downstream Processing Market Segmentation, By Application

10.1 Monoclonal Antibody Production

10.2 Vaccine Production

10.3 Insulin Production

10.4 Immunoglobulin Production

10.5 Erythropoietin Production

11. Downstream Processing Market Segmentation, By End User

11.1 Biopharmaceutical Manufacturers

11.2 Contract Manufacturing Organizations (CMOs)

12. Regional Analysis

12.1 Introduction

12.2 North America

12.2.1 USA

12.2.2 Canada

12.2.3 Mexico

12.3 Europe

12.3.1 Germany

12.3.2 UK

12.3.3 France

12.3.4 Italy

12.3.5 Spain

12.3.6 The Netherlands

12.3.7 Rest of Europe

12.4 Asia-Pacific

12.4.1 Japan

12.4.2 South Korea

12.4.3 China

12.4.4 India

12.4.5 Australia

12.4.6 Rest of Asia-Pacific

12.5 The Middle East & Africa

12.5.1 Israel

12.5.2 UAE

12.5.3 South Africa

12.5.4 Rest

12.6 Latin America

12.6.1 Brazil

12.6.2 Argentina

12.6.3 Rest of Latin America

13. Company Profiles

13.1 Asahi Kasei Corporation

13.1.1 Financial

13.1.2 Products/ Services Offered

13.1.3 SWOT Analysis

13.1.4 The SNS view

13.2 Boehringer Ingelheim

13.3 Corning Incorporated

13.4 Danaher Corporation

13.5 Eppendorf AG

13.6 3M Company

13.7 Merck Millipore

13.8 Lonza Group AG

13.9 Sartorius Stedim Biotech S.A.

13.10 Thermo Fisher Scientific Inc.

14. Competitive Landscape

14.1 Competitive Benchmark

14.2 Market Share Analysis

14.3 Recent Developments

15. Conclusion

An accurate research report requires proper strategizing as well as implementation. There are multiple factors involved in the completion of good and accurate research report and selecting the best methodology to compete the research is the toughest part. Since the research reports we provide play a crucial role in any company’s decision-making process, therefore we at SNS Insider always believe that we should choose the best method which gives us results closer to reality. This allows us to reach at a stage wherein we can provide our clients best and accurate investment to output ratio.

Each report that we prepare takes a timeframe of 350-400 business hours for production. Starting from the selection of titles through a couple of in-depth brain storming session to the final QC process before uploading our titles on our website we dedicate around 350 working hours. The titles are selected based on their current market cap and the foreseen CAGR and growth.


The 5 steps process:

Step 1: Secondary Research:

Secondary Research or Desk Research is as the name suggests is a research process wherein, we collect data through the readily available information. In this process we use various paid and unpaid databases which our team has access to and gather data through the same. This includes examining of listed companies’ annual reports, Journals, SEC filling etc. Apart from this our team has access to various associations across the globe across different industries. Lastly, we have exchange relationships with various university as well as individual libraries.

Secondary Research

Step 2: Primary Research

When we talk about primary research, it is a type of study in which the researchers collect relevant data samples directly, rather than relying on previously collected data.  This type of research is focused on gaining content specific facts that can be sued to solve specific problems. Since the collected data is fresh and first hand therefore it makes the study more accurate and genuine.

We at SNS Insider have divided Primary Research into 2 parts.

Part 1 wherein we interview the KOLs of major players as well as the upcoming ones across various geographic regions. This allows us to have their view over the market scenario and acts as an important tool to come closer to the accurate market numbers. As many as 45 paid and unpaid primary interviews are taken from both the demand and supply side of the industry to make sure we land at an accurate judgement and analysis of the market.

This step involves the triangulation of data wherein our team analyses the interview transcripts, online survey responses and observation of on filed participants. The below mentioned chart should give a better understanding of the part 1 of the primary interview.

Primary Research

Part 2: In this part of primary research the data collected via secondary research and the part 1 of the primary research is validated with the interviews from individual consultants and subject matter experts.

Consultants are those set of people who have at least 12 years of experience and expertise within the industry whereas Subject Matter Experts are those with at least 15 years of experience behind their back within the same space. The data with the help of two main processes i.e., FGDs (Focused Group Discussions) and IDs (Individual Discussions). This gives us a 3rd party nonbiased primary view of the market scenario making it a more dependable one while collation of the data pointers.

Step 3: Data Bank Validation

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Data Bank Validation

Step 4: QA/QC Process

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