The Protein Crystallization Market size was estimated USD 1.24 billion in 2023 and is expected to reach USD 2.34 billion by 2031 at a CAGR of 8.26% during the forecast period of 2024-2031.
Protein crystallization is the process of creating protein crystals from a solution that is supersaturated in the macromolecule but does not disrupt its normal state. Protein crystallization is the creation of an orderly array of individual protein molecules in the form of crystals. These protein crystals are made for scientific and industrial uses, primarily for X-ray crystallography research.
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Several developing proteomics players are receiving financing and investments in order to advance proteomics applications. For example, in January 2023, Evosep, a proteomics technology business, obtained a USD 40 million investment from Novo Holdings to develop a high-throughput proteomics solution. Furthermore, various investments under government initiatives are growing the use of protein crystallization in proteomics research and development.
DRIVERS
Increasing demand for protein therapeutics
Protein treatments have become an important aspect of the healthcare industry in recent years. Protein treatments are frequently used to treat a variety of serious diseases, including cancer, due to their low immunogenicity and specificity. The execution of expansion strategies by manufacturers to secure the biggest market share in response to increased demand for protein-based medications and therapies will boost market growth. In January 2022, for example, Amgen and Generate Biomedicines cooperated to find and develop protein therapeutics for five targets across multiple treatment modalities and therapeutic domains. As a result, rising demand for protein therapies, as well as leading industry players' strategies, will drive market growth over the forecast period.
RESTRAIN
Protein crystallization complexity
Both X-ray crystallography and formulation development require high-quality protein crystals; this difficult process begins with a pure, highly concentrated protein sample in solution. In an ideal world, the liquid component of the solution gradually evaporates, leaving protein crystals in its stead. For some proteins, this technique routinely produces high-quality crystals. For example, crystalline insulin is used as a long-acting insulin substitute. Producing high-quality crystals from other proteins is significantly more difficult.
OPPORTUNITY
Technological progress
Technological advancements in crystallization methods, such as cell-free protein crystallization methods, are expected to give appealing market opportunities during the forecast period. Scientists at the Tokyo Institute of Technology, for example, developed a groundbreaking cell-free protein crystallization process in October 2022. The method adds greatly to structural biology improvements by permitting the analysis of unstable proteins that cannot be explored using other traditional approaches. Such advancements promote the development of novel and improved protein crystal treatments for a wide range of ailments, including cancer and muscular dystrophy.
CHALLENGES
Maintaining their stability throughout the crystallization process
Proteins are not inherently crystallizable substances and inherently complicated and sensitive substances. Maintaining its stability during the crystallization process might be a difficult task in the protein crystallization business. Temperature, pH, protein concentration, and other factors affect protein stability and cause aggregation or denaturation, which can disrupt crystals. As a result, maintaining the proper environment has become a difficult issue in the protein crystallization business. Obtaining adequate quantities of pure and high-quality protein samples might be another issue, particularly for membrane proteins or protein complexes.
The Russian Ukraine war influence on many aspects of daily life, including a considerable load on the healthcare system, and is particularly affecting research trials. Clinical trials are a set of events in which patients are screened, recruited, dossed, followed-up, tracked, and monitored to test the safety and efficacy of a medicine in patients, and regulatory organizations give approvals based on the data acquired. Ukraine has been a popular location for clinical trials because it has a well-established centralized healthcare system that allows pharmaceutical companies to recruit more easily and quickly. Furthermore, Ukraine has a substantial number of treatment-naive patients as well as GCP-compliant workforce and infrastructure. With the conflict still going on, there are numerous circumstances affecting the entire clinical trials system, including the unavailability of new and ongoing patients, as well as a blocked supply chain, which will and has damaged the whole pharmaceutical sector.
IMPACT OF ONGOING RECESSION
Economic downturns or recessions have a negative impact on our operating results since our customers frequently reduce or postpone capital expenditures. Customers may potentially acquire lower-cost products from competitors and not return to us even if economic conditions improve. These circumstances would lower our revenues and profits. Furthermore, a worldwide financial crisis affecting financial institutions would most likely have a negative impact on global capital markets and our industry.
By Product
Instruments
Liquid Handling Instruments
Crystal Imaging Instruments
Consumables
Reagents & Kits/Screens
Micro Plates
Others
Software & Services
In 2023, Consumables segment is expected to held the highest market share of 67.2% during the forecast period due to consumables include reagents and kits/screens, microplates, and other products used to support crystallization processes. Protein crystallization kits offer an efficient screening tool for establishing the ideal solubility conditions for protein crystallization. These kits also include the chemicals needed for fast screening to find the optimal conditions for crystallization of purified protein samples.
By Technology
X-ray Crystallography
Cryo-electron Microscopy
NMR Spectroscopy
Others
In 2023, the X-ray Crystallography segment is expected to dominate the market growth of 53.5% during the forecast period due to X-ray crystallography is the most often used technique for determining the structure of biological macromolecules and proteins. It entails crystallizing proteins, bombarding them with X-rays, and reconstructing their structure based on the tell-tale patterns of diffracted light that occur. The method has various advantages, including a two-dimensional image that indicates the three-dimensional structure of a protein. Furthermore, X-ray crystallography is generally easy and inexpensive, gives superior diffraction, reduces radiation damage to crystals, and allows for safe crystal storage, transit, and reuse. These technological skills are strengthening the segment.
By End User
Pharmaceutical and Biotechnology Companies
Academic and Research Institutes
In 2023, Pharmaceutical and Biotechnology Companies segment is expected to dominate the market growth of 71.7% during the forecast period to due to the Protein crystallization technologies play two important functions in structural biology: in silico drug design and controlled drug discovery. Protein crystallography in silico drug design determines a molecule's 3-D structure. Protein crystal formation resulted in more precise 3-D protein structures. These high-quality crystals may eventually lead to a better understanding of biological function and improved drug creation in pharmaceutical and biotechnology companies.
North America held a significant market share of around 37.3% in 2023 owing to the rising private-sector investment, government aid, and favorable laws. The region is primarily focused on drug development and proteome structure prediction research, which is pushing market expansion. The presence of innovators and important operational players has resulted in greater product penetration in the region.
Asia-Pacific is witness to expand fastest CAGR rate during the forecast period due to the rapid expansion of emerging economies such as China and India's pharmaceutical and biotechnology industries. This region's profitable expansion can also be attributed to continued government backing for the development of the pharmaceutical sector in developing countries. Furthermore, continuing research in the realms of cancer and infectious diseases such as COVID-19 is likely to boost significant growth in the region's protein crystallization market.
REGIONAL COVERAGE
North America
US
Canada
Mexico
Europe
Eastern Europe
Poland
Romania
Hungary
Turkey
Rest of Eastern Europe
Western Europe
Germany
France
UK
Italy
Spain
Netherlands
Switzerland
Austria
Rest of Western Europe
Asia Pacific
China
India
Japan
South Korea
Vietnam
Singapore
Australia
Rest of Asia Pacific
Middle East & Africa
Middle East
UAE
Egypt
Saudi Arabia
Qatar
Rest of Middle East
Africa
Nigeria
South Africa
Rest of Africa
Latin America
Brazil
Argentina
Colombia
Rest of Latin America
The major key players are Rigaku Corporation, FORMULATRIX, METTLER TOLEDO, Corning Incorporated, Greiner Bio-One International GmbH, HAMPTON RESEARCH CORP, Jena Bioscience GmbH, Bruker, Creative Proteomics, Molecular Dimensions, and Others.
METTLER TOLEDO, in July 2022, METTLER TOLEDO announced plans to expand its manufacturing facilities in Vacaville, California. This initiative is designed to strengthen the company's protein crystallization capabilities in Vacaville.
Bruker Corporation, in March 2021, Bruker Corporation announced the launch of new plasma proteomics software, PaSER software v.1.1, which will allow “run & done” high-throughput 4D proteomics with immediate availability of identified peptides and protein groups after the experiment is done. In the same announcement, the company unveiled new consumables and software for chemical cross linking of proteins to study protein structure and interactions.
| Report Attributes | Details |
| Market Size in 2023 | US$ 1.24 Billion |
| Market Size by 2031 | US$ 2.34 Billion |
| CAGR | CAGR of 8.26 % From 2024 to 2031 |
| Base Year | 2023 |
| Forecast Period | 2024-2031 |
| Historical Data | 2020-2022 |
| Report Scope & Coverage | Market Size, Segments Analysis, Competitive Landscape, Regional Analysis, DROC & SWOT Analysis, Forecast Outlook |
| Key Segments | • By Product (Instruments, Consumables, Software & Services) • By Technology (X-ray Crystallography, Cryo-electron Microscopy, NMR Spectroscopy, Others) • By End User (Pharmaceutical and Biotechnology Companies, Academic and Research Institutes) |
| Regional Analysis/Coverage | North America (US, Canada, Mexico), Europe (Eastern Europe [Poland, Romania, Hungary, Turkey, Rest of Eastern Europe] Western Europe] Germany, France, UK, Italy, Spain, Netherlands, Switzerland, Austria, Rest of Western Europe]), Asia Pacific (China, India, Japan, South Korea, Vietnam, Singapore, Australia, Rest of Asia Pacific), Middle East & Africa (Middle East [UAE, Egypt, Saudi Arabia, Qatar, Rest of Middle East], Africa [Nigeria, South Africa, Rest of Africa], Latin America (Brazil, Argentina, Colombia Rest of Latin America) |
| Company Profiles | Rigaku Corporation, FORMULATRIX, METTLER TOLEDO, Corning Incorporated, Greiner Bio-One International GmbH, HAMPTON RESEARCH CORP, Jena Bioscience GmbH, Bruker, Creative Proteomics, Molecular Dimensions |
| Key Drivers | • Increasing demand for protein therapeutics |
| Market Opportunity | • Technological progress |
Ans: Protein Crystallization Market size was valued at USD 1.24 billion in 2023.
Ans: Protein Crystallization Market is anticipated to expand by 8.26% from 2024 to 2031.
Ans: USD 2.34 billion is expected to grow by 2031.
Ans: Rising demand for protein therapeutics.
Ans: Maintaining their stability during the process of crystallization.
Table of Contents
1. Introduction
1.1 Market Definition
1.2 Scope
1.3 Research Assumptions
2. Research Methodology
3. Market Dynamics
3.1 Drivers
3.2 Restraints
3.3 Opportunities
3.4 Challenges
4. Impact Analysis
4.1 Impact of the Ukraine- Russia war
4.2 Impact of ongoing Recession
4.2.1 Introduction
4.2.2 Impact on major economies
4.2.2.1 US
4.2.2.2 Canada
4.2.2.3 Germany
4.2.2.4 France
4.2.2.5 United Kingdom
4.2.2.6 China
4.2.2.7 Japan
4.2.2.8 South Korea
4.2.2.9 Rest of the World
5. Value Chain Analysis
6. Porter’s 5 forces model
7. PEST Analysis
8. Protein Crystallization Market Segmentation, By Product
8.1Instruments
8.1.1Liquid Handling Instruments
8.1.2Crystal Imaging Instruments
8.2Consumables
8.2.1Reagents & Kits/Screens
8.2.2Micro Plates
8.2.3Others
8.3Software & Services Trypsin
9. Protein Crystallization Market Segmentation, By Technology
9.1X-ray Crystallography
9.2Cryo-electron Microscopy
9.3NMR Spectroscopy
9.4Others
10. Protein Crystallization Market Segmentation, By End User
10.1Pharmaceutical And Biotechnology Companies
10.2Academic And Research Institutes
11. Regional Analysis
11.1 Introduction
11.2 North America
11.2.1 North America Protein Crystallization Market by Country
11.2.2 North America Protein Crystallization Market by Product
11.2.3 North America Protein Crystallization Market by Technology
11.2.4 North America Protein Crystallization Market by End User
11.2.5 USA
11.2.5.1 USA Protein Crystallization Market by Product
11.2.5.2 USA Protein Crystallization Market by Technology
11.2.5.3 USA Protein Crystallization Market by End User
11.2.6 Canada
11.2.6.1 Canada Protein Crystallization Market by Product
11.2.6.2 Canada Protein Crystallization Market by Technology
11.2.6.3 Canada Protein Crystallization Market by End User
11.2.7 Mexico
11.2.7.1 Mexico Protein Crystallization Market by Product
11.2.7.2 Mexico Protein Crystallization Market by Technology
11.2.7.3 Mexico Protein Crystallization Market by End User
11.3 Europe
11.3.1 Eastern Europe
11.3.1.1 Eastern Europe Protein Crystallization Market by Country
11.3.1.2 Eastern Europe Protein Crystallization Market by Product
11.3.1.3 Eastern Europe Protein Crystallization Market by Technology
11.3.1.4 Eastern Europe Protein Crystallization Market by End User
11.3.1.5 Poland
11.3.1.5.1 Poland Protein Crystallization Market by Product
11.3.1.5.2 Poland Protein Crystallization Market by Technology
11.3.1.5.3 Poland Protein Crystallization Market by End User
11.3.1.6 Romania
11.3.1.6.1 Romania Protein Crystallization Market by Product
11.3.1.6.2 Romania Protein Crystallization Market by Technology
11.3.1.6.4 Romania Protein Crystallization Market by End User
11.3.1.7 Turkey
11.3.1.7.1 Turkey Protein Crystallization Market by Product
11.3.1.7.2 Turkey Protein Crystallization Market by Technology
11.3.1.7.3 Turkey Protein Crystallization Market by End User
11.3.1.8 Rest of Eastern Europe
11.3.1.8.1 Rest of Eastern Europe Protein Crystallization Market by Product
11.3.1.8.2 Rest of Eastern Europe Protein Crystallization Market by Technology
11.3.1.8.3 Rest of Eastern Europe Protein Crystallization Market by End User
11.3.2 Western Europe
11.3.2.1 Western Europe Protein Crystallization Market by Product
11.3.2.2 Western Europe Protein Crystallization Market by Technology
11.3.2.3 Western Europe Protein Crystallization Market by End User
11.3.2.4 Germany
11.3.2.4.1 Germany Protein Crystallization Market by Product
11.3.2.4.2 Germany Protein Crystallization Market by Technology
11.3.2.4.3 Germany Protein Crystallization Market by End User
11.3.2.5 France
11.3.2.5.1 France Protein Crystallization Market by Product
11.3.2.5.2 France Protein Crystallization Market by Technology
11.3.2.5.3 France Protein Crystallization Market by End User
11.3.2.6 UK
11.3.2.6.1 UK Protein Crystallization Market by Product
11.3.2.6.2 UK Protein Crystallization Market by Technology
11.3.2.6.3 UK Protein Crystallization Market by End User
11.3.2.7 Italy
11.3.2.7.1 Italy Protein Crystallization Market by Product
11.3.2.7.2 Italy Protein Crystallization Market by Technology
11.3.2.7.3 Italy Protein Crystallization Market by End User
11.3.2.8 Spain
11.3.2.8.1 Spain Protein Crystallization Market by Product
11.3.2.8.2 Spain Protein Crystallization Market by Technology
11.3.2.8.3 Spain Protein Crystallization Market by End User
11.3.2.9 Netherlands
11.3.2.9.1 Netherlands Protein Crystallization Market by Product
11.3.2.9.2 Netherlands Protein Crystallization Market by Technology
11.3.2.9.3 Netherlands Protein Crystallization Market by End User
11.3.2.10 Switzerland
11.3.2.10.1 Switzerland Protein Crystallization Market by Product
11.3.2.10.2 Switzerland Protein Crystallization Market by Technology
11.3.2.10.3 Switzerland Protein Crystallization Market by End User
11.3.2.11.1 Austria
11.3.2.11.2 Austria Protein Crystallization Market by Product
11.3.2.11.3 Austria Protein Crystallization Market by Technology
11.3.2.11.4 Austria Protein Crystallization Market by End User
11.3.2.12 Rest of Western Europe
11.3.2.12.1 Rest of Western Europe Protein Crystallization Market by Product
11.3.2.12.2 Rest of Western Europe Protein Crystallization Market by Technology
11.3.2.12.3 Rest of Western Europe Protein Crystallization Market by End User
11.4 Asia-Pacific
11.4.1 Asia-Pacific Protein Crystallization Market by Country
11.4.2 Asia-Pacific Protein Crystallization Market by Product
11.4.3 Asia-Pacific Protein Crystallization Market by Technology
11.4.4 Asia-Pacific Protein Crystallization Market by End User
11.4.5 China
11.4.5.1 China Protein Crystallization Market by Product
11.4.5.2 China Protein Crystallization Market by End User
11.4.5.3 China Protein Crystallization Market by Technology
11.4.6 India
11.4.6.1 India Protein Crystallization Market by Product
11.4.6.2 India Protein Crystallization Market by Technology
11.4.6.3 India Protein Crystallization Market by End User
11.4.7 Japan
11.4.7.1 Japan Protein Crystallization Market by Product
11.4.7.2 Japan Protein Crystallization Market by Technology
11.4.7.3 Japan Protein Crystallization Market by End User
11.4.8 South Korea
11.4.8.1 South Korea Protein Crystallization Market by Product
11.4.8.2 South Korea Protein Crystallization Market by Technology
11.4.8.3 South Korea Protein Crystallization Market by End User
11.4.9 Vietnam
11.4.9.1 Vietnam Protein Crystallization Market by Product
11.4.9.2 Vietnam Protein Crystallization Market by Technology
11.4.9.3 Vietnam Protein Crystallization Market by End User
11.4.10 Singapore
11.4.10.1 Singapore Protein Crystallization Market by Product
11.4.10.2 Singapore Protein Crystallization Market by Technology
11.4.10.3 Singapore Protein Crystallization Market by End User
11.4.11 Australia
11.4.11.1 Australia Protein Crystallization Market by Product
11.4.11.2 Australia Protein Crystallization Market by Technology
11.4.11.3 Australia Protein Crystallization Market by End User
11.4.12 Rest of Asia-Pacific
11.4.12.1 Rest of Asia-Pacific Protein Crystallization Market by Product
11.4.12.2 Rest of Asia-Pacific Protein Crystallization Market by Technology
11.4.12.3 Rest of Asia-Pacific Protein Crystallization Market by End User
11.5 Middle East & Africa
11.5.1 Middle East
11.5.1.1 Middle East Protein Crystallization Market by Country
11.5.1.2 Middle East Protein Crystallization Market by Product
11.5.1.3 Middle East Protein Crystallization Market by Technology
11.5.1.4 Middle East Protein Crystallization Market by End User
11.5.1.5 UAE
11.5.1.5.1 UAE Protein Crystallization Market by Product
11.5.1.5.2 UAE Protein Crystallization Market by Technology
11.5.1.5.3 UAE Protein Crystallization Market by End User
11.5.1.6 Egypt
11.5.1.6.1 Egypt Protein Crystallization Market by Product
11.5.1.6.2 Egypt Protein Crystallization Market by Technology
11.5.1.6.3 Egypt Protein Crystallization Market by End User
11.5.1.7 Saudi Arabia
11.5.1.7.1 Saudi Arabia Protein Crystallization Market by Product
11.5.1.7.2 Saudi Arabia Protein Crystallization Market by Technology
11.5.1.7.3 Saudi Arabia Protein Crystallization Market by End User
11.5.1.8 Qatar
11.5.1.8.1 Qatar Protein Crystallization Market by Product
11.5.1.8.2 Qatar Protein Crystallization Market by Technology
11.5.1.8.3 Qatar Protein Crystallization Market by End User
11.5.1.9 Rest of Middle East
11.5.1.9.1 Rest of Middle East Protein Crystallization Market by Product
11.5.1.9.2 Rest of Middle East Protein Crystallization Market by Technology
11.5.1.9.3 Rest of Middle East Protein Crystallization Market by End User
11.5.2 Africa
11.5.2.1 Africa Transfusion Diagnostics Market by Country
11.5.2.2 Africa Protein Crystallization Market by Product
11.5.2.3 Africa Protein Crystallization Market by Technology
11.5.2.4 Africa Protein Crystallization Market by End User
11.5.2.5 Nigeria
11.5.2.5.1 Nigeria Protein Crystallization Market by Product
11.5.2.5.2 Nigeria Protein Crystallization Market by Technology
11.5.2.5.3 Nigeria Protein Crystallization Market by End User
11.5.2.6 South Africa
11.5.2.6.1 South Africa Protein Crystallization Market by Product
11.5.2.6.2 South Africa Protein Crystallization Market by Technology
11.5.2.6.3 South Africa Protein Crystallization Market by End User
11.5.2.7 Rest of Africa
11.5.2.7.1 Rest of Africa Protein Crystallization Market by Product
11.5.2.7.2 Rest of Africa Protein Crystallization Market by Technology
11.5.2.7.3 Rest of Africa Protein Crystallization Market by End User
11.6 Latin America
11.6.1 Latin America Protein Crystallization Market by Country
11.6.2 Latin America Protein Crystallization Market by Product
11.6.3 Latin America Protein Crystallization Market by Technology
11.6.4 Latin America Protein Crystallization Market by End User
11.6.5 Brazil
11.6.5.1 Brazil Protein Crystallization Market by Product
11.6.5.2 Brazil Protein Crystallization Market by Technology
11.6.5.3 Brazil Protein Crystallization Market by End User
11.6.6 Argentina
11.6.6.1 Argentina Protein Crystallization Market by Product
11.6.6.2 Argentina Protein Crystallization Market by Technology
11.6.6.3 Argentina Protein Crystallization Market by End User
11.6.7 Colombia
11.6.7.1 Colombia Protein Crystallization Market by Product
11.6.7.2 Colombia Protein Crystallization Market by Technology
11.6.7.3 Colombia Protein Crystallization Market by End User
11.6.8 Rest of Latin America
11.6.8.1 Rest of Latin America Protein Crystallization Market by Product
11.6.8.2 Rest of Latin America Protein Crystallization Market by Technology
11.6.8.3 Rest of Latin America Protein Crystallization Market by End User
12. Company profile
12.1 Rigaku Corporation
12.1.1 Company Overview
12.1.2 Financial
12.1.3 Products/ Services Offered
12.1.4 SWOT Analysis
12.1.5 The SNS View
12.2 FORMULATRIX
12.2.1 Company Overview
12.2.2 Financials
12.2.3 Product/Services Offered
12.2.4 SWOT Analysis
12.2.5 The SNS View
12.3 METTLER TOLEDO
12.3.1 Company Overview
12.3.2 Financials
12.3.3 Product/Services Offered
12.3.4 SWOT Analysis
12.3.5 The SNS View
12.4 Corning Incorporated
12.4.1 Company Overview
12.4.2 Financials
12.4.3 Product/Services Offered
12.4.4 SWOT Analysis
12.4.5 The SNS View
12.5 Greiner Bio-One International GmbH
12.5.1 Company Overview
12.5.2 Financials
12.5.3 Product/Services Offered
12.5.4 SWOT Analysis
12.5.5 The SNS View
12.6 HAMPTON RESEARCH CORP
12.6.1 Company Overview
12.6.2 Financials
12.6.3 Product/Services Offered
12.6.4 SWOT Analysis
12.6.5 The SNS View
12.7 Jena Bioscience GmbH
12.7.1 Company Overview
12.7.2 Financials
12.7.3 Product/Services Offered
12.7.4 SWOT Analysis
12.7.5 The SNS View
12.8 Bruker
12.8.1 Company Overview
12.8.2 Financials
12.8.3 Product/Services Offered
12.8.4 SWOT Analysis
12.8.5 The SNS View
12.9 Creative Proteomics
12.9.1 Company Overview
12.9.2 Financials
12.9.3 Product/Services Offered
12.9.4 SWOT Analysis
12.9.5 The SNS View
12.10 Molecular Dimensions.
12.10.1 Company Overview
12.10.2 Financials
12.10.3 Product/Services Offered
12.10.4 SWOT Analysis
12.10.5 The SNS View
12.11 Others
13. Competitive Landscape
13.1 Competitive Bench marking
13.2 Market Share Analysis
13.3 Recent Developments
13.3.1 Industry News
13.3.2 Company News
13.3.3 Mergers & Acquisitions
14. Use Case and Best Practices
15. Conclusion
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