The Protein Crystallization Market size was estimated USD 1.24 billion in 2023 and is expected to reach USD 2.34 billion by 2031 at a CAGR of 8.26% during the forecast period of 2024-2031.
Protein crystallization is the process of creating protein crystals from a solution that is supersaturated in the macromolecule but does not disrupt its normal state. Protein crystallization is the creation of an orderly array of individual protein molecules in the form of crystals. These protein crystals are made for scientific and industrial uses, primarily for X-ray crystallography research.
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Several developing proteomics players are receiving financing and investments in order to advance proteomics applications. For example, in January 2023, Evosep, a proteomics technology business, obtained a USD 40 million investment from Novo Holdings to develop a high-throughput proteomics solution. Furthermore, various investments under government initiatives are growing the use of protein crystallization in proteomics research and development.
DRIVERS
Increasing demand for protein therapeutics
Protein treatments have become an important aspect of the healthcare industry in recent years. Protein treatments are frequently used to treat a variety of serious diseases, including cancer, due to their low immunogenicity and specificity. The execution of expansion strategies by manufacturers to secure the biggest market share in response to increased demand for protein-based medications and therapies will boost market growth. In January 2022, for example, Amgen and Generate Biomedicines cooperated to find and develop protein therapeutics for five targets across multiple treatment modalities and therapeutic domains. As a result, rising demand for protein therapies, as well as leading industry players' strategies, will drive market growth over the forecast period.
RESTRAIN
Protein crystallization complexity
Both X-ray crystallography and formulation development require high-quality protein crystals; this difficult process begins with a pure, highly concentrated protein sample in solution. In an ideal world, the liquid component of the solution gradually evaporates, leaving protein crystals in its stead. For some proteins, this technique routinely produces high-quality crystals. For example, crystalline insulin is used as a long-acting insulin substitute. Producing high-quality crystals from other proteins is significantly more difficult.
OPPORTUNITY
Technological progress
Technological advancements in crystallization methods, such as cell-free protein crystallization methods, are expected to give appealing market opportunities during the forecast period. Scientists at the Tokyo Institute of Technology, for example, developed a groundbreaking cell-free protein crystallization process in October 2022. The method adds greatly to structural biology improvements by permitting the analysis of unstable proteins that cannot be explored using other traditional approaches. Such advancements promote the development of novel and improved protein crystal treatments for a wide range of ailments, including cancer and muscular dystrophy.
CHALLENGES
Maintaining their stability throughout the crystallization process
Proteins are not inherently crystallizable substances and inherently complicated and sensitive substances. Maintaining its stability during the crystallization process might be a difficult task in the protein crystallization business. Temperature, pH, protein concentration, and other factors affect protein stability and cause aggregation or denaturation, which can disrupt crystals. As a result, maintaining the proper environment has become a difficult issue in the protein crystallization business. Obtaining adequate quantities of pure and high-quality protein samples might be another issue, particularly for membrane proteins or protein complexes.
The Russian Ukraine war influence on many aspects of daily life, including a considerable load on the healthcare system, and is particularly affecting research trials. Clinical trials are a set of events in which patients are screened, recruited, dossed, followed-up, tracked, and monitored to test the safety and efficacy of a medicine in patients, and regulatory organizations give approvals based on the data acquired. Ukraine has been a popular location for clinical trials because it has a well-established centralized healthcare system that allows pharmaceutical companies to recruit more easily and quickly. Furthermore, Ukraine has a substantial number of treatment-naive patients as well as GCP-compliant workforce and infrastructure. With the conflict still going on, there are numerous circumstances affecting the entire clinical trials system, including the unavailability of new and ongoing patients, as well as a blocked supply chain, which will and has damaged the whole pharmaceutical sector.
IMPACT OF ECONOMIC DOWNTURN
Economic downturns or recessions have a negative impact on our operating results since our customers frequently reduce or postpone capital expenditures. Customers may potentially acquire lower-cost products from competitors and not return to us even if economic conditions improve. These circumstances would lower our revenues and profits. Furthermore, a worldwide financial crisis affecting financial institutions would most likely have a negative impact on global capital markets and our industry.
By Product
Instruments
Liquid Handling Instruments
Crystal Imaging Instruments
Consumables
Reagents & Kits/Screens
Micro Plates
Others
Software & Services
In 2023, Consumables segment is expected to held the highest market share of 67.2% during the forecast period due to consumables include reagents and kits/screens, microplates, and other products used to support crystallization processes. Protein crystallization kits offer an efficient screening tool for establishing the ideal solubility conditions for protein crystallization. These kits also include the chemicals needed for fast screening to find the optimal conditions for crystallization of purified protein samples.
By Technology
X-ray Crystallography
Cryo-electron Microscopy
NMR Spectroscopy
Others
In 2023, the X-ray Crystallography segment is expected to dominate the market growth of 53.5% during the forecast period due to X-ray crystallography is the most often used technique for determining the structure of biological macromolecules and proteins. It entails crystallizing proteins, bombarding them with X-rays, and reconstructing their structure based on the tell-tale patterns of diffracted light that occur. The method has various advantages, including a two-dimensional image that indicates the three-dimensional structure of a protein. Furthermore, X-ray crystallography is generally easy and inexpensive, gives superior diffraction, reduces radiation damage to crystals, and allows for safe crystal storage, transit, and reuse. These technological skills are strengthening the segment.
By End User
Pharmaceutical and Biotechnology Companies
Academic and Research Institutes
In 2023, Pharmaceutical and Biotechnology Companies segment is expected to dominate the market growth of 71.7% during the forecast period to due to the Protein crystallization technologies play two important functions in structural biology: in silico drug design and controlled drug discovery. Protein crystallography in silico drug design determines a molecule's 3-D structure. Protein crystal formation resulted in more precise 3-D protein structures. These high-quality crystals may eventually lead to a better understanding of biological function and improved drug creation in pharmaceutical and biotechnology companies.
North America held a significant market share of around 37.3% in 2023 owing to the rising private-sector investment, government aid, and favorable laws. The region is primarily focused on drug development and proteome structure prediction research, which is pushing market expansion. The presence of innovators and important operational players has resulted in greater product penetration in the region.
Asia-Pacific is witness to expand fastest CAGR rate during the forecast period due to the rapid expansion of emerging economies such as China and India's pharmaceutical and biotechnology industries. This region's profitable expansion can also be attributed to continued government backing for the development of the pharmaceutical sector in developing countries. Furthermore, continuing research in the realms of cancer and infectious diseases such as COVID-19 is likely to boost significant growth in the region's protein crystallization market.
REGIONAL COVERAGE
North America
US
Canada
Mexico
Europe
Eastern Europe
Poland
Romania
Hungary
Turkey
Rest of Eastern Europe
Western Europe
Germany
France
UK
Italy
Spain
Netherlands
Switzerland
Austria
Rest of Western Europe
Asia Pacific
China
India
Japan
South Korea
Vietnam
Singapore
Australia
Rest of Asia Pacific
Middle East & Africa
Middle East
UAE
Egypt
Saudi Arabia
Qatar
Rest of Middle East
Africa
Nigeria
South Africa
Rest of Africa
Latin America
Brazil
Argentina
Colombia
Rest of Latin America
The major key players are FORMULATRIX, Rigaku Corporation, METTLER TOLEDO, Greiner Bio-One International GmbH, Corning Incorporated, HAMPTON RESEARCH CORP, Jena Bioscience GmbH, Bruker,Molecular Dimensions, Creative Proteomics, and Others.
METTLER TOLEDO, in July 2022, METTLER TOLEDO announced plans to expand its manufacturing facilities in Vacaville, California. This initiative is designed to strengthen the company's protein crystallization capabilities in Vacaville.
Bruker Corporation, in March 2021, Bruker Corporation announced the launch of new plasma proteomics software, PaSER software v.1.1, which will allow “run & done” high-throughput 4D proteomics with immediate availability of identified peptides and protein groups after the experiment is done. In the same announcement, the company unveiled new consumables and software for chemical cross linking of proteins to study protein structure and interactions.
| Report Attributes | Details |
| Market Size in 2023 | US$ 1.24 Billion |
| Market Size by 2031 | US$ 2.34 Billion |
| CAGR | CAGR of 8.26 % From 2024 to 2031 |
| Base Year | 2023 |
| Forecast Period | 2024-2031 |
| Historical Data | 2020-2022 |
| Report Scope & Coverage | Market Size, Segments Analysis, Competitive Landscape, Regional Analysis, DROC & SWOT Analysis, Forecast Outlook |
| Key Segments | • By Product (Instruments, Consumables, Software & Services) • By Technology (X-ray Crystallography, Cryo-electron Microscopy, NMR Spectroscopy, Others) • By End User (Pharmaceutical and Biotechnology Companies, Academic and Research Institutes) |
| Regional Analysis/Coverage | North America (US, Canada, Mexico), Europe (Eastern Europe [Poland, Romania, Hungary, Turkey, Rest of Eastern Europe] Western Europe] Germany, France, UK, Italy, Spain, Netherlands, Switzerland, Austria, Rest of Western Europe]), Asia Pacific (China, India, Japan, South Korea, Vietnam, Singapore, Australia, Rest of Asia Pacific), Middle East & Africa (Middle East [UAE, Egypt, Saudi Arabia, Qatar, Rest of Middle East], Africa [Nigeria, South Africa, Rest of Africa], Latin America (Brazil, Argentina, Colombia Rest of Latin America) |
| Company Profiles | FORMULATRIX, Rigaku Corporation, METTLER TOLEDO, Greiner Bio-One International GmbH, Corning Incorporated, HAMPTON RESEARCH CORP, Jena Bioscience GmbH, Bruker,Molecular Dimensions, Creative Proteomics, |
| Key Drivers | • Increasing demand for protein therapeutics |
| Market Opportunity | • Technological progress |
Ans: Protein Crystallization Market size was valued at USD 1.24 billion in 2023.
Ans: Protein Crystallization Market is anticipated to expand by 8.26% from 2024 to 2031.
Ans: USD 2.34 billion is expected to grow by 2031.
Ans: Rising demand for protein therapeutics.
Ans: Maintaining their stability during the process of crystallization.
TABLE OF CONTENTS
1. Introduction
1.1 Market Definition
1.2 Scope
1.3 Research Assumptions
2. Industry Flowchart
3. Research Methodology
4. Market Dynamics
4.1 Drivers
4.2 Restraints
4.3 Opportunities
4.4 Challenges
5. Impact Analysis
5.1 Impact of Russia-Ukraine Crisis
5.2 Impact of Economic Slowdown on Major Countries
5.2.1 Introduction
5.2.2 United States
5.2.3 Canada
5.2.4 Germany
5.2.5 France
5.2.6 UK
5.2.7 China
5.2.8 Japan
5.2.9 South Korea
5.2.10 India
6. Value Chain Analysis
7. Porter’s 5 Forces Model
8. Pest Analysis
9. Protein Crystallization Market Segmentation, By Product
9.1 Introduction
9.3 Instruments
9.3.1 Liquid Handling Instruments
9.3.2 Crystal Imaging Instruments
9.4 Consumables
9.4.1Reagents & Kits/Screens
9.4.2 Micro Plates
9.4.3 Others
9.5 Software & Services
10. Protein Crystallization Market Segmentation, By Technology
10.2 Trend Analysis
10.3 X-ray Crystallography
10.4 Cryo-electron Microscopy
10.5 NMR Spectroscopy
11. Protein Crystallization Market Segmentation, By End user
11.1 Introduction
11.3 Pharmaceutical and Biotechnology Companies
11.4 Academic and Research Institutes
12. Regional Analysis
12.1 Introduction
12.2 North America
12.2.1 Trend Analysis
12.2.2 North America Protein Crystallization Market by Country
12.2.3 North America Protein Crystallization Market By Product
12.2.4 North America Protein Crystallization Market By Technology
12.2.5 North America Protein Crystallization Market By End user
12.2.6 USA
12.2.6.1 USA Protein Crystallization Market By Product
12.2.6.2 USA Protein Crystallization Market By Technology
12.2.6.3 USA Protein Crystallization Market By End user
12.2.7 Canada
12.2.7.1 Canada Protein Crystallization Market By Product
12.2.7.2 Canada Protein Crystallization Market By Technology
12.2.7.3 Canada Protein Crystallization Market By End user
12.2.8 Mexico
12.2.8.1 Mexico Protein Crystallization Market By Product
12.2.8.2 Mexico Protein Crystallization Market By Technology
12.2.8.3 Mexico Protein Crystallization Market By End user
12.3 Europe
12.3.1 Trend Analysis
12.3.2 Eastern Europe
12.3.2.1 Eastern Europe Protein Crystallization Market by Country
12.3.2.2 Eastern Europe Protein Crystallization Market By Product
12.3.2.3 Eastern Europe Protein Crystallization Market By Technology
12.3.2.4 Eastern Europe Protein Crystallization Market By End user
12.3.2.5 Poland
12.3.2.5.1 Poland Protein Crystallization Market By Product
12.3.2.5.2 Poland Protein Crystallization Market By Technology
12.3.2.5.3 Poland Protein Crystallization Market By End user
12.3.2.6 Romania
12.3.2.6.1 Romania Protein Crystallization Market By Product
12.3.2.6.2 Romania Protein Crystallization Market By Technology
12.3.2.6.4 Romania Protein Crystallization Market By End user
12.3.2.7 Hungary
12.3.2.7.1 Hungary Protein Crystallization Market By Product
12.3.2.7.2 Hungary Protein Crystallization Market By Technology
12.3.2.7.3 Hungary Protein Crystallization Market By End user
12.3.2.8 Turkey
12.3.2.8.1 Turkey Protein Crystallization Market By Product
12.3.2.8.2 Turkey Protein Crystallization Market By Technology
12.3.2.8.3 Turkey Protein Crystallization Market By End user
12.3.2.9 Rest of Eastern Europe
12.3.2.9.1 Rest of Eastern Europe Protein Crystallization Market By Product
12.3.2.9.2 Rest of Eastern Europe Protein Crystallization Market By Technology
12.3.2.9.3 Rest of Eastern Europe Protein Crystallization Market By End user
12.3.3 Western Europe
12.3.3.1 Western Europe Protein Crystallization Market by Country
12.3.3.2 Western Europe Protein Crystallization Market By Product
12.3.3.3 Western Europe Protein Crystallization Market By Technology
12.3.3.4 Western Europe Protein Crystallization Market By End user
12.3.3.5 Germany
12.3.3.5.1 Germany Protein Crystallization Market By Product
12.3.3.5.2 Germany Protein Crystallization Market By Technology
12.3.3.5.3 Germany Protein Crystallization Market By End user
12.3.3.6 France
12.3.3.6.1 France Protein Crystallization Market By Product
12.3.3.6.2 France Protein Crystallization Market By Technology
12.3.3.6.3 France Protein Crystallization Market By End user
12.3.3.7 UK
12.3.3.7.1 UK Protein Crystallization Market By Product
12.3.3.7.2 UK Protein Crystallization Market By Technology
12.3.3.7.3 UK Protein Crystallization Market By End user
12.3.3.8 Italy
12.3.3.8.1 Italy Protein Crystallization Market By Product
12.3.3.8.2 Italy Protein Crystallization Market By Technology
12.3.3.8.3 Italy Protein Crystallization Market By End user
12.3.3.9 Spain
12.3.3.9.1 Spain Protein Crystallization Market By Product
12.3.3.9.2 Spain Protein Crystallization Market By Technology
12.3.3.9.3 Spain Protein Crystallization Market By End user
12.3.3.10 Netherlands
12.3.3.10.1 Netherlands Protein Crystallization Market By Product
12.3.3.10.2 Netherlands Protein Crystallization Market By Technology
12.3.3.10.3 Netherlands Protein Crystallization Market By End user
12.3.3.11 Switzerland
12.3.3.11.1 Switzerland Protein Crystallization Market By Product
12.3.3.11.2 Switzerland Protein Crystallization Market By Technology
12.3.3.11.3 Switzerland Protein Crystallization Market By End user
12.3.3.1.12 Austria
12.3.3.12.1 Austria Protein Crystallization Market By Product
12.3.3.12.2 Austria Protein Crystallization Market By Technology
12.3.3.12.3 Austria Protein Crystallization Market By End user
12.3.3.13 Rest of Western Europe
12.3.3.13.1 Rest of Western Europe Protein Crystallization Market By Product
12.3.3.13.2 Rest of Western Europe Protein Crystallization Market By Technology
12.3.3.13.3 Rest of Western Europe Protein Crystallization Market By End user
12.4 Asia-Pacific
12.4.1 Trend Analysis
12.4.2 Asia-Pacific Protein Crystallization Market by Country
12.4.3 Asia-Pacific Protein Crystallization Market By Product
12.4.4 Asia-Pacific Protein Crystallization Market By Technology
12.4.5 Asia-Pacific Protein Crystallization Market By End user
12.4.6 China
12.4.6.1 China Protein Crystallization Market By Product
12.4.6.2 China Protein Crystallization Market By Technology
12.4.6.3 China Protein Crystallization Market By End user
12.4.7 India
12.4.7.1 India Protein Crystallization Market By Product
12.4.7.2 India Protein Crystallization Market By Technology
12.4.7.3 India Protein Crystallization Market By End user
12.4.8 Japan
12.4.8.1 Japan Protein Crystallization Market By Product
12.4.8.2 Japan Protein Crystallization Market By Technology
12.4.8.3 Japan Protein Crystallization Market By End user
12.4.9 South Korea
12.4.9.1 South Korea Protein Crystallization Market By Product
12.4.9.2 South Korea Protein Crystallization Market By Technology
12.4.9.3 South Korea Protein Crystallization Market By End user
12.4.10 Vietnam
12.4.10.1 Vietnam Protein Crystallization Market By Product
12.4.10.2 Vietnam Protein Crystallization Market By Technology
12.4.10.3 Vietnam Protein Crystallization Market By End user
12.4.11 Singapore
12.4.11.1 Singapore Protein Crystallization Market By Product
12.4.11.2 Singapore Protein Crystallization Market By Technology
12.4.11.3 Singapore Protein Crystallization Market By End user
12.4.12 Australia
12.4.12.1 Australia Protein Crystallization Market By Product
12.4.12.2 Australia Protein Crystallization Market By Technology
12.4.12.3 Australia Protein Crystallization Market By End user
12.4.13 Rest of Asia-Pacific
12.4.13.1 Rest of Asia-Pacific Protein Crystallization Market By Product
12.4.13.2 Rest of Asia-Pacific Protein Crystallization Market By Technology
12.4.13.3 Rest of Asia-Pacific Protein Crystallization Market By End user
12.5 Middle East & Africa
12.5.1 Trend Analysis
12.5.2 Middle East
12.5.2.1 Middle East Protein Crystallization Market by Country
12.5.2.2 Middle East Protein Crystallization Market By Product
12.5.2.3 Middle East Protein Crystallization Market By Technology
12.5.2.4 Middle East Protein Crystallization Market By End user
12.5.2.5 UAE
12.5.2.5.1 UAE Protein Crystallization Market By Product
12.5.2.5.2 UAE Protein Crystallization Market By Technology
12.5.2.5.3 UAE Protein Crystallization Market By End user
12.5.2.6 Egypt
12.5.2.6.1 Egypt Protein Crystallization Market By Product
12.5.2.6.2 Egypt Protein Crystallization Market By Technology
12.5.2.6.3 Egypt Protein Crystallization Market By End user
12.5.2.7 Saudi Arabia
12.5.2.7.1 Saudi Arabia Protein Crystallization Market By Product
12.5.2.7.2 Saudi Arabia Protein Crystallization Market By Technology
12.5.2.7.3 Saudi Arabia Protein Crystallization Market By End user
12.5.2.8 Qatar
12.5.2.8.1 Qatar Protein Crystallization Market By Product
12.5.2.8.2 Qatar Protein Crystallization Market By Technology
12.5.2.8.3 Qatar Protein Crystallization Market By End user
12.5.2.9 Rest of Middle East
12.5.2.9.1 Rest of Middle East Protein Crystallization Market By Product
12.5.2.9.2 Rest of Middle East Protein Crystallization Market By Technology
12.5.2.9.3 Rest of Middle East Protein Crystallization Market By End user
12.5.3 Africa
12.5.3.1 Africa Protein Crystallization Market by Country
12.5.3.2 Africa Protein Crystallization Market By Product
12.5.3.3 Africa Protein Crystallization Market By Technology
12.5.3.4 Africa Protein Crystallization Market By End user
12.5.3.5 Nigeria
12.5.3.5.1 Nigeria Protein Crystallization Market By Product
12.5.3.5.2 Nigeria Protein Crystallization Market By Technology
12.5.3.5.3 Nigeria Protein Crystallization Market By End user
12.5.3.6 South Africa
12.5.3.6.1 South Africa Protein Crystallization Market By Product
12.5.3.6.2 South Africa Protein Crystallization Market By Technology
12.5.3.6.3 South Africa Protein Crystallization Market By End user
12.5.3.7 Rest of Africa
12.5.3.7.1 Rest of Africa Protein Crystallization Market By Product
12.5.3.7.2 Rest of Africa Protein Crystallization Market By Technology
12.5.3.7.3 Rest of Africa Protein Crystallization Market By End user
12.6 Latin America
12.6.1 Trend Analysis
12.6.2 Latin America Protein Crystallization Market by country
12.6.3 Latin America Protein Crystallization Market By Product
12.6.4 Latin America Protein Crystallization Market By Technology
12.6.5 Latin America Protein Crystallization Market By End user
12.6.6 Brazil
12.6.6.1 Brazil Protein Crystallization Market By Product
12.6.6.2 Brazil Protein Crystallization Market By Technology
12.6.6.3 Brazil Protein Crystallization Market By End user
12.6.7 Argentina
12.6.7.1 Argentina Protein Crystallization Market By Product
12.6.7.2 Argentina Protein Crystallization Market By Technology
12.6.7.3 Argentina Protein Crystallization Market By End user
12.6.8 Colombia
12.6.8.1 Colombia Protein Crystallization Market By Product
12.6.8.2 Colombia Protein Crystallization Market By Technology
12.6.8.3 Colombia Protein Crystallization Market By End user
12.6.9 Rest of Latin America
12.6.9.1 Rest of Latin America Protein Crystallization Market By Product
12.6.9.2 Rest of Latin America Protein Crystallization Market By Technology
12.6.9.3 Rest of Latin America Protein Crystallization Market By End user
13. Company Profiles
13.1 Rigaku Corporation
13.1.1 Company Overview
13.1.2 Financial
13.1.3 Product/ Services Offered
13.1.4 SWOT Analysis
13.1.5 The SNS View
13.2 METTLER TOLEDO
13.2.1 Company Overview
13.2.2 Financial
13.2.3 Product / Services Offered
13.2.4 SWOT Analysis
13.2.5 The SNS View
13.3 FORMULATRIX
13.3.1 Company Overview
13.3.2 Financial
13.3.3 Product / Services Offered
13.3.4 SWOT Analysis
13.3.5 The SNS View
13.4 Corning Incorporated
13.4.1 Company Overview
13.4.2 Financial
13.4.3 Product / Services Offered
13.4.4 SWOT Analysis
13.4.5 The SNS View
13.5 Greiner Bio-One International GmbH
13.5.1 Company Overview
13.5.2 Financial
13.5.3 Product/ Services Offered
13.5.4 SWOT Analysis
13.5.5 The SNS View
13.6 HAMPTON RESEARCH CORP
13.6.1 Company Overview
13.6.2 Financial
13.6.3 Product/ Services Offered
13.6.4 SWOT Analysis
13.6.5 The SNS View
13.7 Jena Bioscience GmbH
13.7.1 Company Overview
13.7.2 Financial
13.7.3 Product/ Services Offered
13.7.4 SWOT Analysis
13.7.5 The SNS View
13.8.1 Company Overview
13.8.2 Financial
13.8.3 Product/ Services Offered
13.8.4 SWOT Analysis
13.8.5 The SNS View
13.9 Creative Proteomics
13.9.1 Company Overview
13.9.2 Financial
13.9.3 Product/ Services Offered
13.9.4 SWOT Analysis
13.9.5 The SNS View
13.10 Molecular Dimensions
13.10.1 Company Overview
13.10.2 Financial
13.10.3 Product/ Services Offered
13.10.4 SWOT Analysis
13.10.5 The SNS View
14. Competitive Landscape
14.1 Competitive Benchmarking
14.2 Market Share Analysis
14.3 Recent Developments
14.3.1 Industry News
14.3.2 Company News
14.3.3 Mergers & Acquisitions
15. Use Case and Best Practices
16. Conclusion
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